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NPFFR2 [plasma membrane]
Stable Identifier
R-HSA-389476
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Neuropeptide FF receptor 2; AltName: Full=Neuropeptide G-protein coupled receptor; AltName: Full=G-protein coupled receptor 74; AltName: Full=G-protein coupled receptor HLWAR77;
GN Name=NPFFR2; Synonyms=GPR74, NPFF2, NPGPR;
OS Homo sapiens, NPFF2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
Two NPFF receptors can bind neuropeptide FF (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
NPFFR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5X5 NPFFR2
Gene Names
NPFFR2, GPR74, NPFF2, NPGPR
Chain
chain:1-522
Reference Genes
BioGPS Gene:10886 NPFFR2
COSMIC (genes):NPFFR2 NPFFR2
CTD Gene:10886 NPFFR2
dbSNP Gene:10886 NPFFR2
ENSEMBL:ENSG00000056291 NPFFR2
ENSEMBL_homo_sapiens_GENE:ENSG00000056291.19 NPFFR2
HGNC:4525 NPFFR2
KEGG Gene (Homo sapiens):10886 NPFFR2
Monarch:10886 NPFFR2
NCBI Gene:10886 NPFFR2
OMIM:607449 NPFFR2
UCSC:Q9Y5X5 NPFFR2
Reference Transcript
RefSeq:NM_053036.2 NPFFR2
RefSeq:NM_004885.2 NPFFR2
RefSeq:NM_001144756.1 NPFFR2
Other Identifiers
10886
11756628_a_at
16967664
224169_PM_at
224169_at
2730939
2730940
2730941
2730943
2730947
2730952
2730953
2730955
2730956
2730957
2730958
8095616
A_14_P134741
A_23_P155900
A_24_P71890
GE58350
GO:0004930
GO:0005515
GO:0005856
GO:0005886
GO:0007165
GO:0007186
GO:0007218
GO:0008188
GO:0009582
GO:0015629
GO:0016020
GO:0023052
GO:0031628
GO:0032870
GO:0036211
GO:0042277
GO:0043226
GO:0043408
GO:0045761
GO:0060089
GO:2000479
HMNXSV003045952
ILMN_1739690
ILMN_1751493
ILMN_2307851
PH_hs_0005517
TC04000397.hg
g9309468_3p_at
Participates
as a member of
NPFFR1,NPFFR2 [plasma membrane] (Homo sapiens)
Inferred To
NPFFR2 [plasma membrane]
(Bos taurus)
NPFFR2 [plasma membrane]
(Canis familiaris)
NPFFR2 [plasma membrane]
(Gallus gallus)
NPFFR2 [plasma membrane]
(Sus scrofa)
npffr2a [plasma membrane]
(Danio rerio)
SIFaR [plasma membrane]
(Drosophila melanogaster)
Npffr2 [plasma membrane]
(Mus musculus)
Npffr2 [plasma membrane]
(Rattus norvegicus)
npffr2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_444264.1
,
NP_001138228.1
,
NP_004876.2
Guide to Pharmacology - Targets
301
OpenTargets
ENSG00000056291
ZINC - Substances
NPFF2_HUMAN
HPA
ENSG00000056291-NPFFR2
GeneCards
Q9Y5X5
ZINC target
Q9Y5X5
Ensembl
ENST00000395999
,
ENSG00000056291
,
ENSP00000307822
,
ENSP00000351599
,
ENST00000308744
,
ENST00000358749
,
ENSP00000379321
PRO
Q9Y5X5
Pharos - Targets
Q9Y5X5
ZINC - Predictions - Purchasable
NPFF2_HUMAN
HMDB Protein
HMDBP07848
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