Reactome | Orexin 1 receptor can bind orexin-A neuropeptide

Orexin 1 receptor can bind orexin-A neuropeptide

Stable Identifier

R-HSA-389481

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
        
        Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)

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Orexin 1 receptor can bind orexin-A neuropeptide

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The orexin (hypocretin) neuropeptides (A and B) both derive from a 131 residue precursor, prepro-orexin peptide (Sakurai T et al, 1999). Orexin A (Takai T et al, 2006) binds preferentially to the orphan GPCR orexin 1 receptor (Sakurai T et al, 1998). This activated complex can transduce its signal via the Gq class of G protein.

Literature References

PubMed ID	Title	Journal	Year
10364220	Structure and function of human prepro-orexin gene Sakurai, T, Yanagisawa, M, Nakamura, T, Moriguchi, T, Goto, K, Kajiwara, N, Furuya, K	J Biol Chem	1999
16429482	Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor Nagai, K, Nakagawa, A, Nakano, M, Ikegami, T, Aimoto, S, Akutsu, H, Takaya, T, Takai, T	J Pept Sci	2006
9491897	Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Chemelli, RM, Terrett, JA, Haynes, AC, Elshourbagy, NA, Sakurai, T, Matsuzaki, I, Amemiya, A, Yanagisawa, M, Buckingham, RE, Kozlowski, GP, Bergsma, DJ, Liu, WS, Carr, SA, Richardson, JA, Ishii, M, Williams, SC, Wilson, S, Annan, RS, McNulty, DE, Tanaka, H, Arch, JR	Cell	1998