Reactome | HCRT(34-66) [extracellular region]

HCRT(34-66) [extracellular region]

Stable Identifier

R-HSA-389500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Orexin A, RecName: Full=Orexin; AltName: Full=Hypocretin; Short=Hcrt; Contains: RecName: Full=Orexin-A; AltName: Full=Hypocretin-1; Short=Hcrt1; Contains: RecName: Full=Orexin-B; AltName: Full=Hypocretin-2; Short=Hcrt2; Flags: Precursor;
GN Name=HCRT; Synonyms=OX, PPORX, PPOX;
OS Homo sapiens, OREX_HUMAN, HCRT

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43612 HCRT

Gene Names

HCRT, OX, PPORX, PPOX

Chain

signal peptide:1-33, peptide:34-66, peptide:70-97, propeptide:98-131

Reference Genes

BioGPS Gene:3060 HCRT

COSMIC (genes):HCRT HCRT

CTD Gene:3060 HCRT

dbSNP Gene:3060 HCRT

ENSEMBL:ENSG00000161610 HCRT

ENSEMBL_homo_sapiens_GENE:ENSG00000161610.1 HCRT

HGNC:4847 HCRT

KEGG Gene (Homo sapiens):3060 HCRT

Monarch:3060 HCRT

NCBI Gene:3060 HCRT

OMIM:602358 HCRT

UCSC:O43612 HCRT

Reference Transcript

RefSeq:NM_001524.1 HCRT

Other Identifiers

11734517_at

16845073

207642_PM_at

207642_at

3060

31417_at

3757738

3757739

3757740

3757741

3757742

8015572

A_23_P129989

A_33_P3306624

GE588644

GO:0001659

GO:0005184

GO:0005576

GO:0005783

GO:0005791

GO:0006260

GO:0007200

GO:0007204

GO:0007205

GO:0007218

GO:0007268

GO:0007631

GO:0008021

GO:0008156

GO:0023052

GO:0030141

GO:0030431

GO:0031410

GO:0031771

GO:0031772

GO:0042594

GO:0042755

GO:0043226

GO:0043267

GO:0045202

GO:0046928

GO:0048018

GO:0048471

GO:0050877

GO:0051928

GO:0051970

GO:0051971

GO:0060079

GO:0098772

GO:0098794

GO:0120162

HMNXSV003037129

ILMN_2179739

PH_hs_0027899

TC17001527.hg

g4557634_3p_at

Participates

as an input of

Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)

as a member of

Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)

as a component of

HCRTR1:HCRT(34-66) [plasma membrane] (Homo sapiens)

Other forms of this molecule

HCRT(70-97) [extracellular region]

Inferred To

hcrt [extracellular region] (Danio rerio)

hcrt [extracellular region] (Xenopus tropicalis)

HCRT(34-66) [extracellular region] (Bos taurus)

HCRT [extracellular region] (Canis familiaris)

HCRT [extracellular region] (Gallus gallus)

HCRT [extracellular region] (Sus scrofa)

Hcrt [extracellular region] (Mus musculus)

Hcrt [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001515.1

OpenTargets

ENSG00000161610

HPA

ENSG00000161610-HCRT

GeneCards

O43612

Ensembl

ENSP00000293330, ENSG00000161610, ENST00000293330

PRO

O43612

Pharos - Targets

O43612

Orphanet

16189

HMDB Protein

HMDBP02340

PDB

1WSO, 7L1U, 1CQ0, 1R02, 1UVQ

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01909 HLA-DQA1	9	HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130716) HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane] (R-HSA-2130699) HLA class II histocompatibility antigen, DQ [Golgi membrane] (R-HSA-2214382) HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] (R-HSA-2130568) HLA class II histocompatibility antigen, DQ [transport vesicle membrane] (R-HSA-2130733) HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane] (R-HSA-2130595) HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] (R-HSA-2130529) HLA class II histocompatibility antigen, DQ [lysosomal membrane] (R-HSA-2130686) HLA class II histocompatibility antigen, DQ [plasma membrane] (R-HSA-197585)	0.564	2