NADPH regeneration

Stable Identifier
R-HSA-389542
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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NADPH regeneration
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The conversion of isocitrate to 2-oxoglutarate (alpha-ketoglutarate) with the concomitant synthesis of NADPH from NADP+ is thought to play a significant role in supplying NADPH for other reactions in both the cytosol and the peroxisome (Geisbrecht and Gould 1999). The activity of H6PD (Hexose-6-phosphate dehydrogenase) is thought to play a role in maintaining NADP+ : NADPH balance within the endoplasmic reticulum (Zielinska et al. 2011).
Literature References
PubMed ID Title Journal Year
10521434 The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase

Geisbrecht, BV, Gould, SJ

J Biol Chem 1999
21146583 Biochemistry and physiology of hexose-6-phosphate knockout mice

Lavery, GG, Stewart, PM, Zielinska, AE, Walker, EA

Mol. Cell. Endocrinol. 2011
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Event Information
Go Biological Process
NADPH regeneration (0006740)
Orthologous Events
NADPH regeneration (Bos taurus)
NADPH regeneration (Caenorhabditis elegans)
NADPH regeneration (Canis familiaris)
NADPH regeneration (Danio rerio)
NADPH regeneration (Dictyostelium discoideum)
NADPH regeneration (Drosophila melanogaster)
NADPH regeneration (Gallus gallus)
NADPH regeneration (Mus musculus)
NADPH regeneration (Plasmodium falciparum)
NADPH regeneration (Rattus norvegicus)
NADPH regeneration (Saccharomyces cerevisiae)
NADPH regeneration (Schizosaccharomyces pombe)
NADPH regeneration (Sus scrofa)
NADPH regeneration (Xenopus tropicalis)
Cross References
BioModels Database
Authored
D'Eustachio, P  (2009-01-08)
Reviewed
Jassal, B  (2009-02-27)
D'Eustachio, P  (2024-02-08)
Created
D'Eustachio, P  (2009-01-08)
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