Reactome | IDH1 [peroxisomal matrix]

IDH1 [peroxisomal matrix]

Stable Identifier

R-HSA-389546

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Isocitrate dehydrogenase (NADP) cytoplasmic, PICD

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75874 IDH1

Gene Names

IDH1, PICD

Chain

initiator methionine:, chain:2-414

Reference Genes

BioGPS Gene:3417 IDH1

COSMIC (genes):IDH1 IDH1

CTD Gene:3417 IDH1

dbSNP Gene:3417 IDH1

ENSEMBL:ENSG00000138413 IDH1

HGNC:5382 IDH1

KEGG:hsa:3417 IDH1

Monarch:3417 IDH1

NCBI Gene:3417 IDH1

OMIM:147700 IDH1

UCSC:O75874 IDH1

Reference Transcript

Other Identifiers

11718474_a_at

11718475_s_at

11746174_s_at

1555037_PM_a_at

1555037_a_at

16907758

201193_PM_at

201193_at

2597013

2597014

2597015

2597016

2597017

2597019

2597021

2597023

2597025

2597026

2597027

2597028

2597029

2597030

2597031

2597032

2597034

2597035

2597036

2597037

2597038

2597039

2597040

2597041

2597043

2597047

2940675

2940678

2940682

3417

39023_at

64372_r_at

8058552

84040_at

A_24_P696133

GE54157

GO:0000287

GO:0003824

GO:0004450

GO:0005515

GO:0005576

GO:0005737

GO:0005739

GO:0005777

GO:0005782

GO:0005829

GO:0005975

GO:0006097

GO:0006099

GO:0006102

GO:0006103

GO:0006575

GO:0006739

GO:0006749

GO:0006790

GO:0006979

GO:0008585

GO:0014070

GO:0016491

GO:0016616

GO:0022414

GO:0034774

GO:0042802

GO:0042803

GO:0043226

GO:0045296

GO:0046872

GO:0048545

GO:0048856

GO:0050661

GO:0051287

GO:0055086

GO:0060696

GO:0070062

GO:0071071

GO:1904724

GO:1904813

HMNXSV003048486

Hs2.11223.2.S1_3p_s_at

ILMN_1696432

ILMN_2091347

PH_hs_0030991

RNA146914|p0018_imsncRNA51

TC02002726.hg

U62389_at

g5174470_3p_at

g5174470_3p_x_at

Participates

as a member of

Cargo proteins containing PTS1 [peroxisomal matrix] (Homo sapiens)

as a component of

IDH1 dimer [peroxisomal matrix] (Homo sapiens)

Other forms of this molecule

IDH1 [cytosol]

IDH1 [secretory granule lumen]

IDH1 [extracellular region]

IDH1 [tertiary granule lumen]

IDH1 [ficolin-1-rich granule lumen]

IDH1 R132C mutant [cytosol]

IDH1 R132S mutant [cytosol]

IDH1 R132L mutant [cytosol]

IDH1 R132H mutant [cytosol]

Inferred To

IDH1 [peroxisomal matrix] (Bos taurus)

IDH1 [peroxisomal matrix] (Caenorhabditis elegans)

IDH1 [peroxisomal matrix] (Canis familiaris)

IDH1 [peroxisomal matrix] (Danio rerio)

IDH1 [peroxisomal matrix] (Dictyostelium discoideum)

IDH1 [peroxisomal matrix] (Drosophila melanogaster)

IDH1 [peroxisomal matrix] (Gallus gallus)

IDH1 [peroxisomal matrix] (Mus musculus)

IDH1 [peroxisomal matrix] (Rattus norvegicus)

IDH1 [peroxisomal matrix] (Saccharomyces cerevisiae)

IDH1 [peroxisomal matrix] (Schizosaccharomyces pombe)

IDH1 [peroxisomal matrix] (Sus scrofa)

IDH1 [peroxisomal matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001269316.1, NP_001269315.1, NP_005887.2

Guide to Pharmacology - Targets

2884

OpenTargets

ENSG00000138413

ENSEMBL

ENSP00000410513, ENST00000345146, ENSP00000390265, ENSP00000260985, ENST00000446179, ENST00000415913

ZINC - Substances

IDHC_HUMAN

ZINC target

O75874

PRO

O75874

GlyGen

O75874

PDB

8HB9, 4I3L, 6IO0, 5K10, 5K11, 4L06, 5DE1, 7PJN, 6BKZ, 6O2Z, 3MAS, 5L57, 8VHE, 6PAY, 4XRX, 4UMY, 3MAP, 8VHC, 8VH9, 5TQH, 5SVF, 1T09, 4L03, 6BL1, 4KZO, 6BL2, 3INM, 4I3K, 5LGE, 1T0L, 5SUN, 5GIR, 6B0Z, 7PJM, 8BAY, 6BKY, 6O2Y, 5YFM, 4XS3, 8VHB, 6VEI, 3MAR, 8VHD, 4UMX, 5YFN, 6Q6F, 5L58, 6ADG, 8VHA, 4L04, 6VG0, 6BL0, 6BKX, 6U4J

IntEnz

1.1.1.42

HPA

ENSG00000138413-IDH1

Pharos - Targets

O75874

Orphanet

IDH1

ZINC - Predictions - Purchasable

IDHC_HUMAN

HMDB Protein

HMDBP00898

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DP23 CALM1	5	CALM1 [cytosol] (R-HSA-9016707) CALM1 [nucleoplasm] (R-HSA-9016871) CALM1 [plasma membrane] (R-HSA-9016884) Me3K116-CALM1 [cytosol] (R-HSA-9016706) CALM1 [extracellular region] (R-HSA-9016841)	0.65	7
2-oxoglutarate(2-) [ChEBI:16810]	7	2OG [cytoplasm] (R-ALL-5278317) 2OG [endoplasmic reticulum lumen] (R-ALL-1650779) 2OG [peroxisomal matrix] (R-ALL-389537) 2OG [nucleoplasm] (R-ALL-113671) 2OG [extracellular region] (R-ALL-561075) 2OG [mitochondrial matrix] (R-ALL-113594) 2OG [cytosol] (R-ALL-29406)	0.623	13
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3

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