isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Stable Identifier
R-HSA-389550
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxisomal IDH1 (isocitrate dehydrogenase 1) homodimer catalyzes the reaction of isocitrate and NADP+ to form 2-oxoglutarate, CO2, and NADPH + H+. The same enzyme can also localize to the cytosol in at least some cell types (Geisbrecht and Gould 1999; Xu et al. 2004).
Literature References
PubMed ID Title Journal Year
10521434 The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase

Geisbrecht, BV, Gould, SJ

J Biol Chem 1999
15173171 Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

Ding, J, Xu, X, Arnold, E, Huang, Q, Xu, Z, Zhao, J, Peng, B

J Biol Chem 2004
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Catalyst Activity

isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [peroxisomal matrix]

Physical Entity
IDH1 dimer [peroxisomal matrix] (Homo sapiens)
Activity
isocitrate dehydrogenase (NADP+) activity (GO:0004450)
Orthologous Events
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Gallus gallus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-01-08)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-01-08)
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