Reactome | PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP

PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP

Stable Identifier

R-HSA-389652

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal membrane

ReviewStatus

5/5

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PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP

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The peroxisomal membrane transport protein PMP34 mediates the exchange of adenine nucleotides between the cytosol and the peroxisomal matrix. The localization of PMP34 has been established by immunofluoresence studies (Wylin et al. 1998). The cloned human protein restores adenine nucleotide transport in yeast whose endogenous peroxisomal transporter has been disrupted, and has adenine nucleotide transport activity in reconstituted lipid vesicles in vitro (Visser et al. 2002), consistent with its hypothesized role in vivo (Wanders and Waterham 2006).

Literature References

PubMed ID	Title	Journal	Year
9874197	Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii Baes, M, Wylin, T, Brees, C, Van Veldhoven, PP, Fransen, M, Mannaerts, GP	Eur J Biochem	1998
12445829	Identification of human PMP34 as a peroxisomal ATP transporter Visser, WF, van Roermund, CW, Wanders, RJA, Waterham, HR	Biochem Biophys Res Commun	2002
16756494	Biochemistry of mammalian peroxisomes revisited Wanders, RJA, Waterham, HR	Annu Rev Biochem	2006