Reactome | glyoxylate + NADPH + H+ => glycolate + NADP+

glyoxylate + NADPH + H+ => glycolate + NADP+

Stable Identifier

R-HSA-389826

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

glyoxylate + H(+) + NADPH => glycolate + NADP(+)

ReviewStatus

5/5

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glyoxylate + NADPH + H+ => glycolate + NADP+

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Peroxisomal GRHPR catalyzes the reaction of glyoxylate and NADPH + H+ to form glycolate and NADP+. The active form of the enzyme is a monomer (Rumsby and Cregeen 1999); mutations in it are associated with primary hyperoxaluria type II (Cramer et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10484776	The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II Holmes, RP, Ferree, PMPM, Lin, K, Cramer, SD, Milliner, DS	Hum Mol Genet	1999
10524214	Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase Rumsby, G, Cregeen, DP	Biochim Biophys Acta	1999