Reactome | SUMOylation of DDX17 with SUMO1

SUMOylation of DDX17 with SUMO1

Stable Identifier

R-HSA-3900047

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DDX17 is SUMOylated at lysine-50 with SUMO1 or SUMO2 (Mooney et al. 2010, Fuller-Pace and Nicol 2012, Impens et al. 2014). SUMOylation reduces the transactivation activity of DDX17 with the estrogen receptor and with p53. SUMOylation also promotes association of DDX17 with HDAC1.

Literature References

PubMed ID	Title	Journal	Year
22713328	DEAD-box RNA helicases as transcription cofactors Fuller-Pace, FV, Nicol, SM	Meth. Enzymol.	2012
19995069	Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential Mooney, SM, Grande, JP, Salisbury, JL, Janknecht, R	Biochemistry	2010
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Radoshevich, L, Cossart, P, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014