SUMOylation of MKL1 with SUMO1

Stable Identifier
R-HSA-3900070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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MKL1 is SUMOylated with SUMO1 at lysine-499, lysine-576, and lysine-624 (Nakagawa and Kuzumaki 2005) SUMOylation represses transcriptional activity of MKL1. MKL1 is a coactivator of SRF.
Literature References
PubMed ID Title Journal Year
16098147 Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification

Kuzumaki, N, Nakagawa, K

Genes Cells 2005
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
Authored
Reviewed
Created
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