Reactome | DDX17 [nucleoplasm]

DDX17 [nucleoplasm]

Stable Identifier

R-HSA-3900090

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable ATP-dependent RNA helicase DDX17 ecNumber3.6.4.13/ecNumber, DDX17_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92841 DDX17

Gene Names

DDX17

Chain

chain:1-729

Reference Genes

COSMIC (genes):DDX17 DDX17

dbSNP Gene:10521 DDX17

ENSEMBL:ENSG00000100201 DDX17

Participates

as an input of

SUMOylation of DDX17 with SUMO1 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K50-DDX17 [nucleoplasm]

Inferred To

Ddx17 [nucleoplasm] (Rattus norvegicus)

Homologues of DDX17 [nucleoplasm] (Dictyostelium discoideum)

Homologues of DDX17 [nucleoplasm] (Drosophila melanogaster)

ddx-17 [nucleoplasm] (Caenorhabditis elegans)

mahe [nucleoplasm] (Drosophila melanogaster)

DmRH5 [nucleoplasm] (Drosophila melanogaster)

DDX17 [nucleoplasm] (Bos taurus)

DDX17 [nucleoplasm] (Canis familiaris)

DDX17 [nucleoplasm] (Dictyostelium discoideum)

DDX17 [nucleoplasm] (Drosophila melanogaster)

DDX17 [nucleoplasm] (Gallus gallus)

DDX17 [nucleoplasm] (Mus musculus)

DDX17 [nucleoplasm] (Plasmodium falciparum)

DDX17 [nucleoplasm] (Saccharomyces cerevisiae)

DDX17 [nucleoplasm] (Schizosaccharomyces pombe)

DDX17 [nucleoplasm] (Sus scrofa)

ddx17 [nucleoplasm] (Xenopus tropicalis)

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.738	5
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.737	7
UniProt:P98175 RBM10	1	RBM10 [nucleoplasm] (R-HSA-9770262)	0.718	6
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.718	6
UniProt:Q8K3Y6 ZCCHV			0.704	6
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.668	4
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.666	4
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.666	4
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.666	4
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.649	7
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.597	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	4
UniProt:Q96T37 RBM15			0.556	5
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.556	3
UniProt:Q8IVT4 Q8IVT4			0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
IntAct:EBI-11522220 LSB3			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.553	2
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3
UniProt:Q15435 PP1R7			0.508	2
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.499	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.499	2
UniProt:Q9JKL7 SREK1			0.482	3
UniProt:O94916 NFAT5			0.471	3
UniProt:Q8IUH3 RBM45			0.462	2