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DDX5 [nucleoplasm]
Stable Identifier
R-HSA-3900136
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Probable ATP-dependent RNA helicase DDX5 ecNumber3.6.4.13/ecNumber, DDX5_HUMAN, p68
Locations in the PathwayBrowser for interactor UniProt:Q01780 EXOSC10
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
DDX5 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
DDX5 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)
DDX5 [nucleoplasm] (Homo sapiens)
SUMOylation of DDX5 with SUMO1 (Homo sapiens)
DDX5 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)
DDX5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17844 DDX5
Gene Names
DDX5, G17P1, HELR, HLR1
Chain
chain:1-614
Reference Genes
BioGPS Gene:1655 DDX5
COSMIC (genes):DDX5 DDX5
CTD Gene:1655 DDX5
dbSNP Gene:1655 DDX5
ENSEMBL:ENSG00000108654 DDX5
HGNC:2746 DDX5
KEGG:hsa:1655 DDX5
Monarch:1655 DDX5
NCBI Gene:1655 DDX5
OMIM:180630 DDX5
UCSC:P17844 DDX5
Reference Transcript
RefSeq:NM_001320595.1 DDX5
RefSeq:NM_004396.4 DDX5
RefSeq:NM_001320596.1 DDX5
Other Identifiers
11733798_at
11745795_s_at
11750815_s_at
11757332_x_at
1655
16654639
16654641
16654643
16654645
16654647
16654649
16654651
16654653
16654655
16654657
16654659
16654661
16654663
16654665
16654667
16654669
16654671
16654673
16654675
16654677
16654679
16654681
16654683
16654685
16654687
16654689
16654691
16654693
16654695
16847820
16847839
18671562
18671563
18671564
18671565
18671566
18671567
18671568
18671569
18671570
18671571
18671572
18671573
18671574
18671575
18671576
18671577
18671578
18678264
200033_PM_at
200033_at
225886_PM_at
225886_at
34647_at
3766890
3766891
3766892
3766894
3766895
3766896
3766897
3766898
3766899
3766900
3766901
3766902
3766903
3766904
3766905
3766906
3766907
3766908
3766909
3766910
3766911
3766912
3766913
3766914
3766915
3766916
3766917
3766918
3766919
3766920
3766921
3766922
3766923
3766924
3766925
3766926
3766927
3766928
3766929
3766930
3766931
3766932
3766933
3766934
3766935
3766936
3766937
3766938
3766939
3766940
3766941
3766942
3766943
3766944
3766945
3766946
3766949
3766951
7892829
7892857
7893407
7893516
7893530
7893841
7894055
7894666
7894685
7894886
7894896
7895517
7896169
7896185
7896247
7896427
7896683
8017634
A_23_P15511
A_33_P3299942
GE81390
GO:0000122
GO:0000380
GO:0000381
GO:0000398
GO:0000956
GO:0001837
GO:0003676
GO:0003723
GO:0003724
GO:0003730
GO:0003824
GO:0004386
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005681
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006397
GO:0008380
GO:0009299
GO:0016020
GO:0016071
GO:0016607
GO:0016787
GO:0016887
GO:0019899
GO:0030154
GO:0030509
GO:0030520
GO:0030521
GO:0031053
GO:0035500
GO:0036002
GO:0043021
GO:0043226
GO:0043517
GO:0045069
GO:0045445
GO:0045667
GO:0046332
GO:0048306
GO:0048511
GO:0050681
GO:0060765
GO:0061614
GO:0070062
GO:0070412
GO:0070878
GO:0071013
GO:0072332
GO:0140098
GO:0140657
GO:1990841
GO:1990904
GO:2001014
HMNXSV003005434
HMNXSV003016222
HMNXSV003017450
HMNXSV003018058
HMNXSV003043648
Hs.279806.0.S1_3p_at
Hs.279806.0.S1_3p_x_at
ILMN_1805344
PH_hs_0014403
TC17001800.hg
TC17001801.hg
X15729_s_at
g13514826_3p_at
p33907
Participates
as a component of
ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
as an input of
DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)
SUMOylation of DDX5 with SUMO1 (Homo sapiens)
PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
as an output of
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Other forms of this molecule
DDX5 [cytosol]
polySUMO2-K53-DDX5 [nucleoplasm]
monoSUMO1-K53-DDX5 [nucleoplasm]
Inferred To
Ghost homologue of DDX5 [nucleoplasm]
(Danio rerio)
DDX5 [nucleoplasm]
(Bos taurus)
DDX5 [nucleoplasm]
(Canis familiaris)
DDX5 [nucleoplasm]
(Dictyostelium discoideum)
DDX5 [nucleoplasm]
(Gallus gallus)
DDX5 [nucleoplasm]
(Mus musculus)
DDX5 [nucleoplasm]
(Plasmodium falciparum)
DDX5 [nucleoplasm]
(Saccharomyces cerevisiae)
DDX5 [nucleoplasm]
(Schizosaccharomyces pombe)
DDX5 [nucleoplasm]
(Sus scrofa)
ddx-17 [nucleoplasm]
(Caenorhabditis elegans)
DmRH5 [nucleoplasm]
(Drosophila melanogaster)
ddx5 [nucleoplasm]
(Xenopus tropicalis)
Ddx5 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_004387.1
,
NP_001307525.1
,
NP_001307524.1
OpenTargets
ENSG00000108654
ENSEMBL
ENST00000577922
,
ENST00000450599
,
ENST00000585111
,
ENSP00000504794
,
ENSP00000225792
,
ENSP00000464337
,
ENST00000225792
,
ENSP00000463168
,
ENSP00000403085
,
ENST00000676785
IntEnz
3.6.4.13
HPA
ENSG00000108654-DDX5
PRO
P17844
Pharos - Targets
P17844
GlyGen
P17844
HMDB Protein
HMDBP11690
PDB
4A4D
,
3FE2
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92841 DDX17
2
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
DDX17 [nucleoplasm]
(R-HSA-3900090)
0.738
5
UniProt:Q9NRR4 DROSHA
1
DROSHA [nucleoplasm]
(R-HSA-1482510)
0.737
6
UniProt:P27958-PRO_0000037577
0.733
12
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.656
6
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.643
4
UniProt:P24928 POLR2A
7
POLR2A [nucleoplasm]
(R-HSA-63502)
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-113420)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-77100)
p-S5,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6814543)
0.641
3
UniProt:Q15797 SMAD1
4
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
SMAD1 [cytosol]
(R-HSA-201468)
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
0.612
4
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.61
4
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.576
4
UniProt:O94916 NFAT5
0.563
4
UniProt:Q99717 SMAD5
3
SMAD5 [cytosol]
(R-HSA-201431)
p-S463,S465-SMAD5 [nucleoplasm]
(R-HSA-201432)
p-S463,S465-SMAD5 [cytosol]
(R-HSA-201473)
0.558
3
UniProt:Q13148 TADBP
0.556
3
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.547
2
UniProt:P31943 HNRNPH1
1
HNRNPH1 [nucleoplasm]
(R-HSA-71941)
0.547
2
UniProt:P04637-7 TP53
0.544
2
UniProt:P04637-1 TP53
0.544
2
UniProt:P22087 FBL
1
FBL [nucleoplasm]
(R-HSA-6790638)
0.543
6
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.527
5
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.527
3
UniProt:Q92841-4 DDX17
0.527
2
UniProt:Q96SB4 SRPK1
2
SRPK1 [nucleoplasm]
(R-HSA-9821984)
SRPK1 [cytosol]
(R-HSA-9729349)
0.527
2
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.524
3
UniProt:P51858 HDGF
1
HDGF [nucleoplasm]
(R-HSA-535593)
0.512
4
UniProt:Q96S59 RANBP9
1
RANBP9 [cytosol]
(R-HSA-374586)
0.508
2
UniProt:P62699 YPEL5
3
YPEL5 [ficolin-1-rich granule lumen]
(R-HSA-6800954)
YPEL5 [extracellular region]
(R-HSA-6806435)
YPEL5 [tertiary granule lumen]
(R-HSA-6800422)
0.508
2
UniProt:Q1K9H5 Q1K9H5
0.508
2
UniProt:Q7L5Y9 MAEA
1
MAEA [cytosol]
(R-HSA-9861711)
0.508
2
UniProt:Q9H871 RMND5A
1
RMND5A [cytosol]
(R-HSA-9861580)
0.508
2
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.499
2
UniProt:Q9UI26 IPO11
0.499
2
UniProt:Q8AZK7 EBNA5
0.499
2
UniProt:P29991-PRO_0000037946
0.488
2
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.483
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.483
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.471
3
UniProt:P10085 Myod1
2
MYOD1_MOUSE [nucleoplasm]
(R-MMU-448840)
Myod1 [nucleoplasm]
(R-MMU-445441)
0.462
3
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