SUMOylation of DDX5 with SUMO1

Stable Identifier
R-HSA-3900177
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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DDX5 is SUMOylated at lysine-53 with SUMO1 (Mooney et al. 2010, Matafora et al. 2009, Impens et al. 2014). SUMOylation enhances coactivation activity of DDX5, stability of DDX5, and interaction of DDX5 with HDAC1.
Literature References
PubMed ID Title Journal Year
19596686 Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition

Blasi, F, Mori, S, Bachi, A, Matafora, V, D'Amato, A

Mol. Cell Proteomics 2009
19995069 Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential

Salisbury, JL, Grande, JP, Janknecht, R, Mooney, SM

Biochemistry 2010
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
Authored
Reviewed
Created
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