Reactome | SUMOylation of DDX5 with SUMO1

SUMOylation of DDX5 with SUMO1

Stable Identifier

R-HSA-3900177

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DDX5 is SUMOylated at lysine-53 with SUMO1 (Mooney et al. 2010, Matafora et al. 2009, Impens et al. 2014). SUMOylation enhances coactivation activity of DDX5, stability of DDX5, and interaction of DDX5 with HDAC1.

Literature References

PubMed ID	Title	Journal	Year
19596686	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition Blasi, F, Mori, S, Bachi, A, Matafora, V, D'Amato, A	Mol. Cell Proteomics	2009
19995069	Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential Salisbury, JL, Grande, JP, Janknecht, R, Mooney, SM	Biochemistry	2010
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Cossart, P, Radoshevich, L, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014