Reactome | polySUMO2-K53-DDX5 [nucleoplasm]

polySUMO2-K53-DDX5 [nucleoplasm]

Stable Identifier

R-HSA-3900186

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable ATP-dependent RNA helicase DDX5 ecNumber3.6.4.13/ecNumber, DDX5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P31749 AKT1

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Literature References

PubMed ID	Title	Journal	Year
17369852	SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1 Jacobs, AM, Nicol, SM, Hislop, RG, Jaffray, EG, Hay, RT, Fuller-Pace, FV	Oncogene	2007
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Radoshevich, L, Cossart, P, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014

External Reference Information

External Reference

UniProt:P17844 DDX5

Gene Names

DDX5, G17P1, HELR, HLR1

Chain

chain:1-614

Reference Genes

BioGPS Gene:1655 DDX5

COSMIC (genes):DDX5 DDX5

CTD Gene:1655 DDX5

dbSNP Gene:1655 DDX5

ENSEMBL:ENSG00000108654 DDX5

HGNC:2746 DDX5

KEGG:hsa:1655 DDX5

Monarch:1655 DDX5

NCBI Gene:1655 DDX5

OMIM:180630 DDX5

UCSC:P17844 DDX5

Reference Transcript

Other Identifiers

11733798_at

11745795_s_at

11750815_s_at

11757332_x_at

1655

16654639

16654641

16654643

16654645

16654647

16654649

16654651

16654653

16654655

16654657

16654659

16654661

16654663

16654665

16654667

16654669

16654671

16654673

16654675

16654677

16654679

16654681

16654683

16654685

16654687

16654689

16654691

16654693

16654695

16847820

16847839

18671562

18671563

18671564

18671565

18671566

18671567

18671568

18671569

18671570

18671571

18671572

18671573

18671574

18671575

18671576

18671577

18671578

18678264

200033_PM_at

200033_at

225886_PM_at

225886_at

34647_at

3766890

3766891

3766892

3766894

3766895

3766896

3766897

3766898

3766899

3766900

3766901

3766902

3766903

3766904

3766905

3766906

3766907

3766908

3766909

3766910

3766911

3766912

3766913

3766914

3766915

3766916

3766917

3766918

3766919

3766920

3766921

3766922

3766923

3766924

3766925

3766926

3766927

3766928

3766929

3766930

3766931

3766932

3766933

3766934

3766935

3766936

3766937

3766938

3766939

3766940

3766941

3766942

3766943

3766944

3766945

3766946

3766949

3766951

7892829

7892857

7893407

7893516

7893530

7893841

7894055

7894666

7894685

7894886

7894896

7895517

7896169

7896185

7896247

7896427

7896683

8017634

A_23_P15511

A_33_P3299942

GE81390

GO:0000122

GO:0000166

GO:0000380

GO:0000381

GO:0000398

GO:0000956

GO:0001837

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0003730

GO:0003824

GO:0004386

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006397

GO:0008380

GO:0009299

GO:0016020

GO:0016071

GO:0016607

GO:0016787

GO:0016887

GO:0019899

GO:0030154

GO:0030509

GO:0030520

GO:0030521

GO:0031053

GO:0035500

GO:0036002

GO:0043021

GO:0043517

GO:0045069

GO:0045445

GO:0045667

GO:0046332

GO:0048306

GO:0048511

GO:0050681

GO:0060765

GO:0061614

GO:0070062

GO:0070412

GO:0070878

GO:0071013

GO:0072332

GO:0140098

GO:0140657

GO:1990841

GO:1990904

GO:2001014

HMNXSV003005434

HMNXSV003016222

HMNXSV003017450

HMNXSV003018058

HMNXSV003043648

Hs.279806.0.S1_3p_at

Hs.279806.0.S1_3p_x_at

ILMN_1805344

PH_hs_0014403

TC17001800.hg

TC17001801.hg

X15729_s_at

g13514826_3p_at

p33907

Participates

as an output of

PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)

Other forms of this molecule

DDX5 [nucleoplasm]

DDX5 [cytosol]

monoSUMO1-K53-DDX5 [nucleoplasm]

Inferred To

DDX5 [nucleoplasm] (Bos taurus)

DDX5 [nucleoplasm] (Gallus gallus)

DDX5 [nucleoplasm] (Sus scrofa)

ddx5 [nucleoplasm] (Danio rerio)

ddx5 [nucleoplasm] (Xenopus tropicalis)

Homologues of polySUMO2-K53-DDX5 [nucleoplasm] (Dictyostelium discoideum)

Ddx5 [nucleoplasm] (Mus musculus)

ddx17 [nucleoplasm] (Dictyostelium discoideum)

polySUMO2-K53-DDX5 [nucleoplasm] (Dictyostelium discoideum)

polySUMO2-K53-DDX5 [nucleoplasm] (Plasmodium falciparum)

polySUMO2-K53-DDX5 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 53

Coordinate

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_004387.1, NP_001307525.1, NP_001307524.1

OpenTargets

ENSG00000108654

ENSEMBL

ENST00000585111, ENSP00000225792, ENSP00000403085, ENST00000577922, ENSG00000108654, ENST00000676785, ENST00000450599, ENST00000225792, ENSP00000504794, ENSP00000463168, ENSP00000464337

IntEnz

3.6.4.13

GeneCards

DDX5

HPA

ENSG00000108654-DDX5

PRO

P17844

Pharos - Targets

P17844

GlyGen

P17844

HMDB Protein

HMDBP11690

PDB

3FE2, 4A4D

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.738	5
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.737	6
UniProt:P27958-PRO_0000037577			0.733	12
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.656	6
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.643	4
UniProt:P24928 POLR2A	8	p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S2(CTD)-POLR2A [nucleoplasm] (R-HSA-9970465)	0.641	3
UniProt:Q15797 SMAD1	4	SMAD1 [cytosol] (R-HSA-201468) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) Ub-SMAD1 [cytosol] (R-HSA-6782768)	0.612	4
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.61	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.576	4
UniProt:O94916 NFAT5			0.563	4
UniProt:Q99717 SMAD5	3	SMAD5 [cytosol] (R-HSA-201431) p-S463,S465-SMAD5 [cytosol] (R-HSA-201473) p-S463,S465-SMAD5 [nucleoplasm] (R-HSA-201432)	0.558	3
UniProt:Q13148 TADBP			0.556	3
UniProt:Q08211 DHX9	3	DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168) DHX9 [nucleoplasm] (R-HSA-53517)	0.547	2
UniProt:P31943 HNRNPH1	2	HNRNPH1 [nucleoplasm] (R-HSA-71941) HNRNPH1 [cytosol] (R-HSA-9947619)	0.547	2
UniProt:P04637-7 TP53			0.544	2
UniProt:P04637-1 TP53			0.544	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.543	6
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.527	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.527	5
UniProt:Q92841-4 DDX17			0.527	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.527	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:P45481 Crebbp	4	Crebbp [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.524	3
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.512	4
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.508	2
UniProt:P62699 YPEL5	3	YPEL5 [tertiary granule lumen] (R-HSA-6800422) YPEL5 [extracellular region] (R-HSA-6806435) YPEL5 [ficolin-1-rich granule lumen] (R-HSA-6800954)	0.508	2
UniProt:Q1K9H5 Q1K9H5			0.508	2
UniProt:Q7L5Y9 MAEA	1	MAEA [cytosol] (R-HSA-9861711)	0.508	2
UniProt:Q9H871 RMND5A	1	RMND5A [cytosol] (R-HSA-9861580)	0.508	2
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.499	2
UniProt:Q9UI26 IPO11			0.499	2
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:P29991-PRO_0000037946			0.488	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.483	3
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.483	2
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12
UniProt:Q01780 EXOSC10	2	EXOSC10 [nucleoplasm] (R-HSA-6791547) EXOSC10 [nucleolus] (R-HSA-9935809)	0.471	3
UniProt:P10085 Myod1	2	Myod1 [nucleoplasm] (R-MMU-448840) Myod1 [nucleoplasm] (R-MMU-445441)	0.462	3

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