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monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm]
Stable Identifier
R-HSA-3900216
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MKL/myocardin-like protein 1, MKL1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of MKL1 with SUMO1 (Homo sapiens)
monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969V6 MRTFA
Gene Names
MRTFA, KIAA1438, MAL, MKL1
Chain
chain:1-931
Reference Genes
BioGPS Gene:57591 MRTFA
COSMIC (genes):MRTFA MRTFA
CTD Gene:57591 MRTFA
dbSNP Gene:57591 MRTFA
ENSEMBL:ENSG00000196588 MKL1
ENSEMBL_homo_sapiens_GENE:ENSG00000196588.21 MRTFA
HGNC:14334 MRTFA
KEGG Gene (Homo sapiens):57591 MRTFA
Monarch:57591 MRTFA
NCBI Gene:57591 MRTFA
OMIM:606078 MRTFA
UCSC:Q969V6 MRTFA
Reference Transcript
RefSeq:NM_020831.4 MRTFA
RefSeq:NM_001282661.1 MRTFA
RefSeq:NM_001282660.1 MRTFA
RefSeq:XM_005261694.1 MRTFA
Other Identifiers
11750940_a_at
11755153_a_at
16935290
212748_PM_at
212748_at
215292_PM_s_at
215292_s_at
35563_at
35629_at
3961495
3961497
3961498
3961499
3961501
3961502
3961503
3961504
3961505
3961506
3961507
3961508
3961509
3961510
3961511
3961514
3961515
3961518
3961522
3961524
3961531
3961532
57591
8076241
A_23_P348138
GE53972
GE82567
GO:0003713
GO:0003779
GO:0003785
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0007010
GO:0008092
GO:0030036
GO:0030154
GO:0042060
GO:0043226
GO:0043522
GO:0044319
GO:0045944
GO:0048856
GO:0048870
GO:0051145
GO:0140110
GO:1902895
HMNXSV003024964
Hs.134751.0.A1_3p_s_at
Hs.31146.0.S1_3p_at
ILMN_1651767
PH_hs_0025047
PH_hs_0033253
p33812
Participates
as an output of
SUMOylation of MKL1 with SUMO1 (Homo sapiens)
Other forms of this molecule
MKL1 [nucleoplasm]
MKL1 [cytosol]
Inferred To
MRTFA [nucleoplasm]
(Bos taurus)
MRTFA [nucleoplasm]
(Sus scrofa)
Mrtfa [nucleoplasm]
(Mus musculus)
Mrtfa [nucleoplasm]
(Rattus norvegicus)
monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm]
(Gallus gallus)
mrtfa [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 499
Coordinate
499
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 576
Coordinate
576
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 624
Coordinate
624
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001269589.1
,
XP_005261751.1
,
NP_065882.1
,
NP_001269590.1
OpenTargets
ENSG00000196588
HPA
ENSG00000196588-MRTFA
GeneCards
Q969V6
Ensembl
ENSG00000196588
,
ENSP00000385835
,
ENST00000407029
PRO
Q969V6
Pharos - Targets
Q969V6
Orphanet
22989
PDB
2KVU
,
2KW9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11831 SRF
2
p-S103 SRF [nucleoplasm]
(R-HSA-9612518)
SRF [nucleoplasm]
(R-HSA-5666000)
0.589
2
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