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monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm]
Stable Identifier
R-HSA-3900216
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MKL/myocardin-like protein 1, MKL1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of MKL1 with SUMO1 (Homo sapiens)
monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969V6 MRTFA
Gene Names
MRTFA, KIAA1438, MAL, MKL1
Chain
chain:1-931
Reference Genes
BioGPS Gene:57591 MRTFA
COSMIC (genes):MAL MRTFA
COSMIC (genes):MRTFA MRTFA
CTD Gene:57591 MRTFA
dbSNP Gene:57591 MRTFA
ENSEMBL:ENSG00000196588 MKL1
HGNC:14334 MRTFA
KEGG:hsa:57591 MRTFA
Monarch:57591 MRTFA
NCBI Gene:57591 MRTFA
OMIM:606078 MRTFA
UCSC:Q969V6 MRTFA
Reference Transcript
RefSeq:NM_020831.4 MRTFA
RefSeq:NM_001282660.1 MRTFA
RefSeq:XM_005261694.1 MRTFA
RefSeq:NM_001282661.1 MRTFA
Other Identifiers
11750940_a_at
11751839_a_at
11755153_a_at
11762343_x_at
1555763_x_at
1559902_PM_at
1559902_at
16935290
212748_PM_at
212748_at
215291_3p_at
215291_PM_at
215291_at
215292_PM_s_at
215292_s_at
2365469
2708797
35563_at
35629_at
3961495
3961497
3961498
3961499
3961501
3961502
3961503
3961504
3961505
3961506
3961507
3961508
3961509
3961510
3961511
3961514
3961515
3961517
3961518
3961520
3961521
3961522
3961524
3961530
3961531
3961532
3961538
3961541
3961542
3961550
3961551
3961556
3961563
3961564
3961565
3961566
3961570
3961575
4073157
57591
8076241
A_23_P348138
A_33_P3415678
GE53972
GE699795
GE82567
GO:0003713
GO:0003779
GO:0003785
GO:0004864
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0007010
GO:0008092
GO:0030036
GO:0030154
GO:0043226
GO:0043522
GO:0044319
GO:0045944
GO:0048870
GO:0051145
GO:0060090
GO:0098772
GO:0098793
GO:0098794
GO:0098978
GO:0099159
GO:0140110
GO:1902895
HMNXSV003000189
HMNXSV003024964
Hs.134751.0.A1_3p_at
Hs.134751.0.A1_3p_s_at
Hs.31146.0.S1_3p_at
Hs2.433153.2.S1_3p_at
Hs2Affx.1.461.S1_3p_x_at
ILMN_1651767
PH_hs_0025047
PH_hs_0033253
TC22000811.hg
p33812
Participates
as an output of
SUMOylation of MKL1 with SUMO1 (Homo sapiens)
Other forms of this molecule
MKL1 [nucleoplasm]
MKL1 [cytosol]
Inferred To
MRTFA [nucleoplasm]
(Bos taurus)
MRTFA [nucleoplasm]
(Sus scrofa)
Mrtfa [nucleoplasm]
(Mus musculus)
Mrtfa [nucleoplasm]
(Rattus norvegicus)
monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm]
(Gallus gallus)
mrtfa [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 499
Coordinate
499
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 576
Coordinate
576
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 624
Coordinate
624
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_065882.1
,
NP_001269590.1
,
XP_005261751.1
,
NP_001269589.1
ENSEMBL
ENST00000407029
,
ENSP00000385835
OpenTargets
ENSG00000196588
HPA
ENSG00000196588-MRTFA
PRO
Q969V6
Pharos - Targets
Q969V6
GlyGen
Q969V6
Orphanet
MRTFA
PDB
2KVU
,
2KW9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11831 SRF
2
p-S103 SRF [nucleoplasm]
(R-HSA-9612518)
SRF [nucleoplasm]
(R-HSA-5666000)
0.589
2
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