1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate

Stable Identifier
Reaction [transition]
Homo sapiens
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Peroxisomal alkylglycerone phosphate synthase (AGPS) catalyzes the reaction of 1-palmitoylglycerone phosphate and hexadecanol to form O-hexadecylglycerone phosphate and palmitate. The active form of the enzyme is post-translationally cleaved to remove its 58 aminoterminal residues, has a molecule of FAD as a cofactor, and occurs in the peroxisome as a complex with glyceronephosphate O-acyltransferase (GNPAT) (Biermann et al. 1999; Bierman and van den Bosch 1999; de Vet et al. 2000).

Literature References
PubMed ID Title Journal Year
10692424 Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide

van den Bosch, H, de Vet, EC, Hilkes, YH, Fraaije, MW

J Biol Chem 2000
10215861 Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes

Biermann, J, Just, WW, van den Bosch, H, Wanders, RJ

Eur J Biochem 1999
10415121 In vitro processing of the human alkyl-dihydroxyacetonephosphate synthase precursor

Biermann, J, van den Bosch, H

Arch Biochem Biophys 1999
Catalyst Activity

alkylglycerone-phosphate synthase activity of GNPAT:AGPS complex [peroxisomal matrix]

Orthologous Events
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