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TCP1 [cytosol]
Stable Identifier
R-HSA-390448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-complex protein 1 subunit alpha (TCP-1-alpha)
Locations in the PathwayBrowser for interactor UniProt:P68363 TUBA1B
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of TCP1 (Homo sapiens)
TCP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17987 TCP1
Gene Names
TCP1, t-complex 1, CCT1, CCTA
Chain
chain:1-556
Reference Genes
BioGPS Gene:6950 TCP1
COSMIC (genes):TCP1 TCP1
CTD Gene:6950 TCP1
dbSNP Gene:6950 TCP1
ENSEMBL:ENSG00000120438 TCP1
HGNC:11655 TCP1
KEGG:hsa:6950 TCP1
Monarch:6950 TCP1
NCBI Gene:6950 TCP1
OMIM:186980 TCP1
UCSC:P17987 TCP1
Reference Transcript
RefSeq:NM_030752.2 TCP1
Other Identifiers
11722018_a_at
11741319_a_at
11757132_at
11763910_at
17025297
17119488
17119490
208778_PM_s_at
208778_s_at
222010_PM_at
222010_at
222011_PM_s_at
222011_s_at
2982382
2982383
2982384
2982385
2982386
2982387
2982388
2982389
2982390
2982391
2982392
2982393
2982394
2982395
2982397
2982398
2982399
2982400
2982401
2982402
2982403
2982404
2982405
2982406
2982407
2982408
2982409
2982411
2982412
2982413
2982414
2982415
2982416
2982417
2982418
2999263
2999271
3407336
3407359
3407360
3407362
3407363
3407365
3407367
34791_at
6950
8130567
8130578
8130580
A_21_P0000316
A_21_P0000319
A_23_P122782
A_33_P3349947
A_33_P3651282
GE61593
GE86458
GO:0000242
GO:0000792
GO:0001669
GO:0002199
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0006457
GO:0007021
GO:0007339
GO:0016787
GO:0016887
GO:0031410
GO:0031625
GO:0032212
GO:0043226
GO:0044183
GO:0044297
GO:0050821
GO:0051082
GO:0051086
GO:0061077
GO:0065003
GO:0070062
GO:0090666
GO:0140657
GO:0140662
GO:1904851
GO:1904871
GO:1904874
HMNXSV003013792
HMNXSV003026139
HMNXSV003046111
HMNXSV003053685
Hs.278544.2.A1_3p_s_at
ILMN_1660661
ILMN_1776347
ILMN_2313434
PH_hs_0000453
RNA33440|snoRNA_scaRNA_36_140
RNA33505|snoRNA_scaRNA_101_132
TC06002277.hg
TC06002278.hg
X52882_at
g12653758_3p_s_at
Participates
as a component of
BBS/CCT complex [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
as an output of
Expression of TCP1 (Homo sapiens)
Inferred To
CCT1 [cytosol]
(Drosophila melanogaster)
Tcp1 [cytosol]
(Mus musculus)
Tcp1 [cytosol]
(Rattus norvegicus)
cct1 [cytosol]
(Schizosaccharomyces pombe)
cct-1 [cytosol]
(Caenorhabditis elegans)
tcp1 [cytosol]
(Danio rerio)
tcp1 [cytosol]
(Dictyostelium discoideum)
tcp1 [cytosol]
(Xenopus tropicalis)
TCP1 [cytosol]
(Bos taurus)
TCP1 [cytosol]
(Canis familiaris)
TCP1 [cytosol]
(Gallus gallus)
TCP1 [cytosol]
(Plasmodium falciparum)
TCP1 [cytosol]
(Saccharomyces cerevisiae)
TCP1 [cytosol]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000120438
ENSEMBL
ENSP00000317334
,
ENST00000321394
HPA
ENSG00000120438-TCP1
PRO
P17987
Pharos - Targets
P17987
GlyGen
P17987
PDB
7X3J
,
7TTN
,
8SG8
,
6NRA
,
7X0S
,
7X0V
,
6NRD
,
7NVO
,
8HKI
,
7NVL
,
7WU7
,
6NRC
,
8SHP
,
6NR9
,
7X7Y
,
7TUB
,
8SGQ
,
8I1U
,
7WZ3
,
8SFE
,
8SHL
,
8SHE
,
7X0A
,
7LUM
,
8SHD
,
8SGC
,
8SG9
,
8SHQ
,
7NVM
,
8IB8
,
7NVN
,
8SHT
,
8I9U
,
7TRG
,
7TTT
,
8SHO
,
6NRB
,
8SHN
,
6NR8
,
7X3U
,
8SH9
,
7LUP
,
6QB8
,
8SFF
,
8SGL
,
7X6Q
,
8SHG
,
8SHF
,
8SHA
Interactors (73)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78371 CCT2
3
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
0.813
7
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.788
7
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.758
5
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.744
4
UniProt:P60510 PPP4C
1
PPP4C [nucleoplasm]
(R-HSA-5687750)
0.725
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.725
4
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.725
6
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.725
5
UniProt:P61962 DCAF7
2
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
DCAF7 [nucleoplasm]
(R-HSA-8863312)
0.706
6
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.69
6
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.669
3
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [cytosol]
(R-HSA-390449)
0.669
3
UniProt:P78380 OLR1
3
OLR1 [tertiary granule membrane]
(R-HSA-6800883)
OLR1 [plasma membrane]
(R-HSA-203139)
OLR1 [specific granule membrane]
(R-HSA-6799518)
0.644
5
UniProt:P83110-2 HTRA3
0.644
7
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.643
3
UniProt:Q9Y2T4 2ABG
0.643
3
UniProt:Q13033 STRN3
0.643
3
UniProt:P68363 TUBA1B
9
TUBA1B [cytosol]
(R-HSA-191691)
TUBA1B [axonemal microtubule]
(R-HSA-5610434)
TUBA1B(1-450) [cytosol]
(R-HSA-8955581)
Polyglutamyl-TUBA1B [cytosol]
(R-HSA-8867435)
L-isoglutamyl polyglycyl-TUBA1B [cytosol]
(R-HSA-8867436)
TUBA1B unfolded [cytosol]
(R-HSA-392781)
TUBA1B folding intermediate [cytosol]
(R-HSA-392797)
Ac K40 TUBA1B [axonemal microtubule]
(R-HSA-5624854)
AcK-TUBA1B [cytosol]
(R-HSA-5618285)
0.643
4
UniProt:P83110-1 HTRA3
0.632
6
UniProt:P83105 HTRA4
0.621
7
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
13
UniProt:Q99759 MAP3K3
1
MAP3K3 [cytosol]
(R-HSA-507725)
0.564
2
UniProt:O43439 CBFA2T2
1
CBFA2T2 [nucleoplasm]
(R-HSA-9827884)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q9ULD4-2 Q9ULD42
0.556
3
UniProt:Q9Y2Y0 ARL2BP
2
ARL2BP [cytosol]
(R-HSA-5215982)
ARL2BP [mitochondrial matrix]
(R-HSA-5250220)
0.556
3
UniProt:P83110 HTRA3
0.537
5
UniProt:Q53HC9 EIPR1
0.527
4
UniProt:Q14990 ODFP1
0.527
2
UniProt:Q15120 PDK3
1
PDK3(?-406) [mitochondrial matrix]
(R-HSA-203940)
0.527
2
UniProt:Q9BQS8 FYCO1
0.527
3
UniProt:Q99592 ZBT18
0.527
2
UniProt:Q9Y2I8 WDR37
0.527
3
UniProt:P52333 JAK3
6
JAK3 [cytosol]
(R-HSA-451893)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-JAK3 [cytosol]
(R-HSA-8982856)
JAK3 [endosome]
(R-HSA-8983184)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
0.527
2
UniProt:P23258 TUBG1
1
TUBG1 [cytosol]
(R-HSA-379269)
0.527
2
UniProt:Q71U36 TUBA1A
9
TUBA1A [cytosol]
(R-HSA-191689)
TUBA1A [axonemal microtubule]
(R-HSA-5610433)
TUBA1A(1-450) [cytosol]
(R-HSA-8955577)
Polyglutamyl-TUBA1A [cytosol]
(R-HSA-8867408)
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
(R-HSA-8867428)
TUBA1A unfolded [cytosol]
(R-HSA-392767)
TUBA1A folding intermediate [cytosol]
(R-HSA-392805)
Ac K40 TUBA1A [axonemal microtubule]
(R-HSA-5624852)
AcK-TUBA1A [cytosol]
(R-HSA-5618312)
0.527
4
UniProt:Q5TAQ9 DCAF8
1
DCAF8 [nucleoplasm]
(R-HSA-8955192)
0.527
4
UniProt:Q9BXA6 TSSK6
0.527
2
UniProt:Q8TEB1 DCAF11
1
DCAF11 [nucleoplasm]
(R-HSA-8863251)
0.527
2
UniProt:O43827 ANGL7
0.527
4
UniProt:Q9NPJ1 MKKS
1
MKKS [cytosol]
(R-HSA-5624086)
0.527
3
UniProt:Q96J01 THOC3
1
THOC3 [nucleoplasm]
(R-HSA-8849121)
0.527
3
UniProt:P78318 IGBP1
0.527
2
UniProt:Q9Y3L5 RAP2C
2
RAP2C [plasma membrane]
(R-HSA-6804983)
RAP2C [tertiary granule membrane]
(R-HSA-6804975)
0.527
3
UniProt:Q13509 TUBB3
6
TUBB3 [cytosol]
(R-HSA-190532)
TUBB3 [axonemal microtubule]
(R-HSA-5610436)
Polyglutamyl-TUBB3 [cytosol]
(R-HSA-8867464)
Polyglycyl-TUBB3 [cytosol]
(R-HSA-8867372)
TUBB3 unfolded [cytosol]
(R-HSA-392770)
TUBB3 folding intermediate [cytosol]
(R-HSA-392806)
0.527
2
UniProt:Q9C0K7 STRADB
1
STRADB [cytosol]
(R-HSA-380976)
0.527
2
UniProt:Q96EX3 DYNC2I2
2
WDR34 [ciliary tip]
(R-HSA-5625407)
WDR34 [cilium]
(R-HSA-5624900)
0.527
2
UniProt:Q86VZ2 WDR5B
0.527
3
UniProt:P57775 FBXW4
1
FBXW4 [cytosol]
(R-HSA-391305)
0.527
3
UniProt:Q9BQ87 TBL1Y
0.527
3
UniProt:Q9H2J4 PDCL3
0.527
3
UniProt:O96019 ACTL6A
1
ACTL6A [nucleoplasm]
(R-HSA-2980912)
0.527
2
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.527
5
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.527
2
UniProt:O00628 PEX7
2
PEX7 [peroxisomal membrane]
(R-HSA-9033493)
PEX7 [cytosol]
(R-HSA-9033107)
0.527
3
UniProt:Q9BQA1 WDR77
3
WDR77 [cytosol]
(R-HSA-191823)
pT5-WDR77 [nucleoplasm]
(R-HSA-5205602)
WDR77 [nucleoplasm]
(R-HSA-5205610)
0.527
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.527
3
UniProt:Q9Y5Z7 HCFC2
1
HCFC2 [nucleoplasm]
(R-HSA-9821232)
0.527
3
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.527
3
UniProt:Q8IYD2 KLD8A
0.527
3
UniProt:Q9BRX9 WDR83
1
WDR83 [endosome membrane]
(R-HSA-5672942)
0.527
4
UniProt:Q96JK2 DCAF5
1
DCAF5 [nucleoplasm]
(R-HSA-8955189)
0.527
4
UniProt:Q9NVX7 KBTB4
0.527
2
UniProt:Q9NRH3 TUBG2
1
TUBG2 [cytosol]
(R-HSA-379272)
0.527
3
UniProt:Q00535 CDK5
4
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [nucleoplasm]
(R-HSA-8863586)
0.527
2
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
2
UniProt:A6NCF5 KLH33
0.527
3
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.527
2
UniProt:Q8NBT0 POC1A
0.483
2
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.462
2
UniProt:Q00005 2ABB
0.462
3
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