Reactome | TCP1 [cytosol]

TCP1 [cytosol]

Stable Identifier

R-HSA-390448

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit alpha (TCP-1-alpha)

Locations in the PathwayBrowser for interactor UniProt:Q00005 2ABB

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of TCP1 (Homo sapiens)
        
        TCP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17987 TCP1

Gene Names

TCP1, t-complex 1, CCT1, CCTA

Chain

chain:1-556

Reference Genes

BioGPS Gene:6950 TCP1

COSMIC (genes):TCP1 TCP1

CTD Gene:6950 TCP1

dbSNP Gene:6950 TCP1

ENSEMBL:ENSG00000120438 TCP1

ENSEMBL_homo_sapiens_GENE:ENSG00000120438.12 TCP1

HGNC:11655 TCP1

KEGG Gene (Homo sapiens):6950 TCP1

Monarch:6950 TCP1

NCBI Gene:6950 TCP1

OMIM:186980 TCP1

UCSC:P17987 TCP1

Reference Transcript

RefSeq:NM_030752.2 TCP1

Other Identifiers

11722018_a_at

11741319_a_at

17025297

208778_PM_s_at

208778_s_at

222010_PM_at

222010_at

222011_PM_s_at

222011_s_at

2982382

2982383

2982384

2982385

2982387

2982389

2982393

2982395

2982400

2982402

2982405

2982409

2982411

2982413

2982417

2982418

2999263

2999271

3407336

3407359

3407360

3407362

3407363

3407365

3407367

34791_at

6950

8130567

A_23_P122782

A_33_P3349947

GE61593

GE86458

GO:0000166

GO:0000242

GO:0000792

GO:0001669

GO:0002199

GO:0003723

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005694

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0007021

GO:0007339

GO:0016787

GO:0016887

GO:0022414

GO:0031410

GO:0031625

GO:0032200

GO:0032212

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0051973

GO:0061077

GO:0065003

GO:0070062

GO:0090666

GO:0140657

GO:0140662

GO:1904851

GO:1904871

GO:1904874

HMNXSV003013792

Hs.278544.2.A1_3p_s_at

ILMN_1660661

ILMN_1776347

ILMN_2313434

PH_hs_0000453

TC06002277.hg

X52882_at

g12653758_3p_s_at

Participates

as a component of

as an output of

Expression of TCP1 (Homo sapiens)

Inferred To

CCT1 [cytosol] (Drosophila melanogaster)

Tcp1 [cytosol] (Mus musculus)

Tcp1 [cytosol] (Rattus norvegicus)

cct1 [cytosol] (Schizosaccharomyces pombe)

cct-1 [cytosol] (Caenorhabditis elegans)

tcp1 [cytosol] (Danio rerio)

tcp1 [cytosol] (Dictyostelium discoideum)

tcp1 [cytosol] (Xenopus tropicalis)

TCP1 [cytosol] (Bos taurus)

TCP1 [cytosol] (Canis familiaris)

TCP1 [cytosol] (Gallus gallus)

TCP1 [cytosol] (Plasmodium falciparum)

TCP1 [cytosol] (Saccharomyces cerevisiae)

TCP1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_110379.2

OpenTargets

ENSG00000120438

GeneCards

P17987

HPA

ENSG00000120438-TCP1

Ensembl

ENST00000321394, ENSG00000120438, ENSP00000317334

PRO

P17987

Pharos - Targets

P17987

PDB

8SHP, 7NVN, 7NVM, 8SHQ, 8SHT, 8SG8, 7TUB, 8SG9, 7WU7, 8SHD, 8SHE, 8IB8, 7X6Q, 8I9U, 7X0V, 8SGC, 8I1U, 8SHF, 7X0S, 8SHG, 7LUP, 7TTN, 6QB8, 7LUM, 7X3J, 8SHL, 8SFE, 6NRD, 6NRC, 8SHN, 8SGQ, 8SFF, 7WZ3, 8SHO, 6NRB, 6NRA, 7X0A, 7X3U, 8SH9, 6NR9, 7X7Y, 7NVL, 6NR8, 8SHA, 7TTT, 8SGL, 7TRG, 8HKI, 7NVO

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.813	7
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.788	7
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.758	5
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.744	4
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.725	5
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.725	6
UniProt:P60510 PPP4C	1	PPP4C [nucleoplasm] (R-HSA-5687750)	0.725	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.706	6
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.69	6
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.669	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.669	3
UniProt:P83110-2 HTRA3			0.644	7
UniProt:P78380 OLR1	3	OLR1 [tertiary granule membrane] (R-HSA-6800883) OLR1 [plasma membrane] (R-HSA-203139) OLR1 [specific granule membrane] (R-HSA-6799518)	0.644	5
UniProt:P68363 TUBA1B	9	AcK-TUBA1B [cytosol] (R-HSA-5618285) Ac K40 TUBA1B [axonemal microtubule] (R-HSA-5624854) TUBA1B folding intermediate [cytosol] (R-HSA-392797) TUBA1B unfolded [cytosol] (R-HSA-392781) L-isoglutamyl polyglycyl-TUBA1B [cytosol] (R-HSA-8867436) Polyglutamyl-TUBA1B [cytosol] (R-HSA-8867435) TUBA1B(1-450) [cytosol] (R-HSA-8955581) TUBA1B [axonemal microtubule] (R-HSA-5610434) TUBA1B [cytosol] (R-HSA-191691)	0.643	4
UniProt:Q13033 STRN3			0.643	3
UniProt:Q9Y2T4 2ABG			0.643	3
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.643	3
UniProt:P83110-1 HTRA3			0.632	6
UniProt:P83105 HTRA4			0.621	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	13
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.564	2
UniProt:O43439 CBFA2T2	1	CBFA2T2 [nucleoplasm] (R-HSA-9827884)	0.556	3
UniProt:Q9Y2Y0 ARL2BP	2	ARL2BP [cytosol] (R-HSA-5215982) ARL2BP [mitochondrial matrix] (R-HSA-5250220)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P83110 HTRA3			0.537	5
UniProt:Q53HC9 EIPR1			0.527	4
UniProt:Q14990 ODFP1			0.527	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q9BQS8 FYCO1			0.527	3
UniProt:Q99592 ZBT18			0.527	2
UniProt:Q9Y2I8 WDR37			0.527	3
UniProt:P23258 TUBG1	1	TUBG1 [cytosol] (R-HSA-379269)	0.527	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.527	4
UniProt:Q5TAQ9 DCAF8	1	DCAF8 [nucleoplasm] (R-HSA-8955192)	0.527	4
UniProt:Q9BXA6 TSSK6			0.527	2
UniProt:Q8TEB1 DCAF11	1	DCAF11 [nucleoplasm] (R-HSA-8863251)	0.527	2
UniProt:O43827 ANGL7			0.527	4
UniProt:Q9NPJ1 MKKS	1	MKKS [cytosol] (R-HSA-5624086)	0.527	3
UniProt:Q96J01 THOC3	1	THOC3 [nucleoplasm] (R-HSA-8849121)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P78318 IGBP1			0.527	2
UniProt:Q9Y3L5 RAP2C	2	RAP2C [plasma membrane] (R-HSA-6804983) RAP2C [tertiary granule membrane] (R-HSA-6804975)	0.527	3
UniProt:Q13509 TUBB3	6	TUBB3 folding intermediate [cytosol] (R-HSA-392806) TUBB3 unfolded [cytosol] (R-HSA-392770) Polyglycyl-TUBB3 [cytosol] (R-HSA-8867372) Polyglutamyl-TUBB3 [cytosol] (R-HSA-8867464) TUBB3 [axonemal microtubule] (R-HSA-5610436) TUBB3 [cytosol] (R-HSA-190532)	0.527	2
UniProt:Q9C0K7 STRADB	1	STRADB [cytosol] (R-HSA-380976)	0.527	2
UniProt:Q96EX3 DYNC2I2	2	WDR34 [ciliary tip] (R-HSA-5625407) WDR34 [cilium] (R-HSA-5624900)	0.527	2
UniProt:Q86VZ2 WDR5B			0.527	3
UniProt:P57775 FBXW4	1	FBXW4 [cytosol] (R-HSA-391305)	0.527	3
UniProt:Q9BQ87 TBL1Y			0.527	3
UniProt:Q9H2J4 PDCL3			0.527	3
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.527	2
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.527	2
UniProt:A6NCF5 KLH33			0.527	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	2
UniProt:Q9NRH3 TUBG2	1	TUBG2 [cytosol] (R-HSA-379272)	0.527	3
UniProt:Q9NVX7 KBTB4			0.527	2
UniProt:Q96JK2 DCAF5	1	DCAF5 [nucleoplasm] (R-HSA-8955189)	0.527	4
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.527	4
UniProt:Q8IYD2 KLD8A			0.527	3
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.527	3
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.527	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.527	2
UniProt:P52333 JAK3	6	p-Y980 JAK3 [cytosol] (R-HSA-9701438) JAK3 [endosome] (R-HSA-8983184) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [cytosol] (R-HSA-451893)	0.527	2
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.527	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	5
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007)	0.527	3
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.527	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q8NBT0 POC1A			0.483	2
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.462	2
UniProt:Q00005 2ABB			0.462	3

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