Folding of actin by CCT/TriC

Stable Identifier
R-HSA-390450
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Folding of actin by CCT/TriC
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Nucleotide-independent transfer of beta-actin from prefoldin to CCT occurs when prefoldin binds to CCT (Vainberg et al., 1998). Following ATP- dependent folding within CCT (Gao et al., 1992), beta-actin is released as a soluble, monomeric protein.
Literature References
PubMed ID Title Journal Year
8104191 Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin

Melki, R, Vainberg, IE, Chow, RL, Cowan, NJ

J Cell Biol 1993
9630229 Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin

Vainberg, IE, Lewis, SA, Rommelaere, H, Ampe, C, Vandekerckhove, J, Klein, HL, Cowan, NJ

Cell 1998
1351421 A cytoplasmic chaperonin that catalyzes beta-actin folding

Gao, Y, Thomas, JO, Chow, RL, Lee, GH, Cowan, NJ

Cell 1992
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Event Information
Go Biological Process
protein folding (0006457)
Authored
Matthews, L  (2008-12-01)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-02-09)
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