Reactome | CCT7 [cytosol]

CCT7 [cytosol]

Stable Identifier

R-HSA-390451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit eta (TCP-1-eta)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99832 CCT7

Gene Names

CCT7, CCTH, NIP7-1

Chain

initiator methionine:1, chain:1-543, chain:2-543

Reference Genes

BioGPS Gene:10574 CCT7

COSMIC (genes):CCT7 CCT7

CTD Gene:10574 CCT7

dbSNP Gene:10574 CCT7

ENSEMBL:ENSG00000135624 CCT7

ENSEMBL:ENSG00000135624.17 CCT7

HGNC:1622 CCT7

KEGG Gene (Homo sapiens):10574 CCT7

Monarch:10574 CCT7

NCBI Gene:10574 CCT7

OMIM:605140 CCT7

UCSC:Q99832 CCT7

Reference Transcript

Other Identifiers

10574

11737913_s_at

16881485

200812_PM_at

200812_at

2488733

2488734

2488737

2488738

2488740

2488742

2488743

2488746

2488747

2488748

2488749

2488750

2488753

2488754

38720_at

8042720

A_23_P102404

GE54204

GO:0000166

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0007339

GO:0016787

GO:0016887

GO:0022414

GO:0032200

GO:0032212

GO:0042026

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0061077

GO:0070062

GO:0140657

GO:0140662

GO:1904851

GO:1904871

GO:1904874

HMNXSV003006334

ILMN_1703718

ILMN_2341793

PH_hs_0024059

PH_hs_0032888

TC02000440.hg

TC02003327.hg

U83843_at

g5453606_3p_at

Participates

as a candidate of

as a component of

Inferred To

Homologues of CCT7 [cytosol] (Canis familiaris)

cct-7 [cytosol] (Caenorhabditis elegans)

cct7 [cytosol] (Dictyostelium discoideum)

cct7 [cytosol] (Schizosaccharomyces pombe)

cct7 [cytosol] (Xenopus tropicalis)

CCT7 [cytosol] (Bos taurus)

CCT7 [cytosol] (Canis familiaris)

CCT7 [cytosol] (Danio rerio)

CCT7 [cytosol] (Drosophila melanogaster)

CCT7 [cytosol] (Gallus gallus)

CCT7 [cytosol] (Plasmodium falciparum)

CCT7 [cytosol] (Saccharomyces cerevisiae)

CCT7 [cytosol] (Sus scrofa)

Cct7 [cytosol] (Mus musculus)

Cct7 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001159757.1, XP_011530780.1, NP_006420.1, NP_001159756.1, NP_001009570.1, XP_011530781.1

OpenTargets

ENSG00000135624

GeneCards

Q99832

HPA

ENSG00000135624-CCT7

Ensembl

ENSP00000442058, ENSP00000381456, ENSP00000258091, ENST00000539919, ENST00000258091, ENSG00000135624, ENSP00000437824, ENST00000398422, ENST00000540468

PRO

Q99832

Pharos - Targets

Q99832

PDB

7TUB, 6NRD, 7WU7, 7TTN, 7WZ3, 7NVM, 6NRA, 7NVL, 7LUP, 7NVO, 7LUM, 6NR9, 6NRC, 7TRG, 7NVN, 6NRB, 6NR8, 6QB8, 7TTT

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	4
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.643	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.527	2
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.527	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9

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