Reactome | CCT4 [cytosol]

CCT4 [cytosol]

Stable Identifier

R-HSA-390458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit delta (TCP-1-delta)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50991 CCT4

Gene Names

CCT4, CCTD, SRB

Chain

initiator methionine:, chain:2-539

Reference Genes

BioGPS Gene:10575 CCT4

COSMIC (genes):CCT4 CCT4

CTD Gene:10575 CCT4

dbSNP Gene:10575 CCT4

ENSEMBL:ENSG00000115484 CCT4

ENSEMBL_homo_sapiens_GENE:ENSG00000115484.15 CCT4

HGNC:1617 CCT4

KEGG Gene (Homo sapiens):10575 CCT4

Monarch:10575 CCT4

NCBI Gene:10575 CCT4

OMIM:605142 CCT4

UCSC:P50991 CCT4

Reference Transcript

Other Identifiers

10575

11732127_a_at

11732128_s_at

11747041_x_at

11749821_x_at

16898175

200877_PM_at

200877_at

2555635

2555636

2555637

2555638

2555639

2555640

2555642

2555646

2555647

2555648

2555650

2555652

2555654

2555655

2555656

2555657

2555660

2555664

2555666

2555672

2555673

2555674

2555675

2555676

32594_at

8052562

A_23_P102420

A_33_P3229397

GE81635

GE88842

GO:0000166

GO:0002199

GO:0003723

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0007339

GO:0016787

GO:0016887

GO:0022414

GO:0031410

GO:0032200

GO:0032212

GO:0042470

GO:0042995

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0051973

GO:0061077

GO:0070062

GO:0090666

GO:0140657

GO:0140662

GO:1904851

GO:1904871

GO:1904874

HMNXSV003020720

ILMN_1776073

PH_hs_0018126

TC02001895.hg

U38846_at

g5453604_3p_s_at

Participates

as a component of

Inferred To

Ghost homologue of CCT4 [cytosol] (Xenopus tropicalis)

tcp-1 delta [cytosol] (Gallus gallus)

cct4 [cytosol] (Danio rerio)

cct4 [cytosol] (Dictyostelium discoideum)

cct4 [cytosol] (Schizosaccharomyces pombe)

CCT4 [cytosol] (Bos taurus)

CCT4 [cytosol] (Canis familiaris)

CCT4 [cytosol] (Drosophila melanogaster)

CCT4 [cytosol] (Plasmodium falciparum)

CCT4 [cytosol] (Saccharomyces cerevisiae)

CCT4 [cytosol] (Sus scrofa)

cct-4 [cytosol] (Caenorhabditis elegans)

Cct4 [cytosol] (Mus musculus)

Cct4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001243650.1, NP_006421.2

OpenTargets

ENSG00000115484

GeneCards

P50991

HPA

ENSG00000115484-CCT4

Ensembl

ENST00000394440, ENSP00000443061, ENSG00000115484, ENST00000544079, ENSP00000377958

PRO

P50991

Pharos - Targets

P50991

PDB

8SHO, 7X0V, 8I9Q, 7NVL, 7WU7, 8IB8, 7NVM, 8I9U, 8I1U, 6NRD, 8SHF, 7NVO, 6QB8, 7X0A, 8HKI, 8SGL, 7LUM, 7TRG, 7X3U, 8SHG, 8SFE, 7TTN, 8SHL, 8SGQ, 8SFF, 7X7Y, 7X0S, 8SHN, 7TTT, 8SG8, 8SH9, 7X6Q, 6NRA, 8SHP, 8SG9, 7TUB, 6NRB, 8SHT, 8SHA, 6NRC, 8SHQ, 8SHE, 7NVN, 8SGC, 7X3J, 8SHD, 7WZ3, 7LUP, 6NR8, 6NR9

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.788	7
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	17
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.669	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.643	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.643	3
UniProt:P78380 OLR1	3	OLR1 [plasma membrane] (R-HSA-203139) OLR1 [tertiary granule membrane] (R-HSA-6800883) OLR1 [specific granule membrane] (R-HSA-6799518)	0.591	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	7
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.527	2
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.527	3
UniProt:Q13882 PTK6	5	p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570) PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007)	0.527	3
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.527	3
UniProt:O94953 KDM4B	2	K48PolyUb-KDM4B [nucleoplasm] (R-HSA-5683074) KDM4B [nucleoplasm] (R-HSA-3214396)	0.527	2
UniProt:Q7Z6Z6 PNPLA5	1	PNPLA5 [cytosol] (R-HSA-8848346)	0.527	2
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.527	3
UniProt:P52333 JAK3	6	p-Y980 JAK3 [cytosol] (R-HSA-9701438) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) JAK3 [endosome] (R-HSA-8983184) p-JAK3 [cytosol] (R-HSA-8982856) p-Y-JAK3 [cytosol] (R-HSA-9006854) JAK3 [cytosol] (R-HSA-451893)	0.527	2

Cite Us!