Reactome | TPM2 [cytosol]

TPM2 [cytosol]

Stable Identifier

R-HSA-390552

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tropomyosin beta chain, TPM2_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Tropomyosin [cytosol] (Homo sapiens)
        
        TPM2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07951 TPM2

Gene Names

TPM2, TMSB

Chain

chain:1-284

Reference Genes

BioGPS Gene:7169 TPM2

COSMIC (genes):TPM2 TPM2

CTD Gene:7169 TPM2

dbSNP Gene:7169 TPM2

ENSEMBL:ENSG00000198467 TPM2

HGNC:12011 TPM2

KEGG:hsa:7169 TPM2

Monarch:7169 TPM2

NCBI Gene:7169 TPM2

OMIM:190990 TPM2

UCSC:P07951 TPM2

Reference Transcript

Participates

as a member of

Tropomyosin [cytosol] (Homo sapiens)

Inferred To

TPM2 [cytosol] (Bos taurus)

TPM2 [cytosol] (Canis familiaris)

TPM2 [cytosol] (Sus scrofa)

Tm1 [cytosol] (Drosophila melanogaster)

Tpm2 [cytosol] (Mus musculus)

Tpm2 [cytosol] (Rattus norvegicus)

lev-11 [cytosol] (Caenorhabditis elegans)

Tm2 [cytosol] (Drosophila melanogaster)

Homologues of TPM1 [cytosol] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000645482, ENST00000378292, ENSG00000198467, ENSP00000367542, ENSP00000496494

OpenTargets

ENSG00000198467

GeneCards

TPM2

HPA

ENSG00000198467-TPM2

PRO

P07951

Pharos - Targets

P07951

GlyGen

P07951

Orphanet

TPM2

HMDB Protein

HMDBP08071

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	16