Reactome | DES [cytosol]

DES [cytosol]

Stable Identifier

R-HSA-390570

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Desmin, DESM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17661 DES

Gene Names

DES

Chain

initiator methionine:, chain:2-470

Reference Genes

BioGPS Gene:1674 DES

COSMIC (genes):DES DES

CTD Gene:1674 DES

dbSNP Gene:1674 DES

ENSEMBL:ENSG00000175084 DES

HGNC:2770 DES

Monarch:1674 DES

NCBI Gene:1674 DES

OMIM:125660 DES

UCSC:P17661 DES

Reference Transcript

RefSeq:NM_001927.3 DES

Other Identifiers

11717048_a_at

11717049_s_at

11717050_x_at

1674

16891261

202222_3p_s_at

202222_PM_s_at

202222_s_at

214027_3p_x_at

214027_PM_x_at

214027_x_at

2528477

2528478

2528479

2528480

2528481

2528482

2528483

2528484

2528485

2528486

2528488

2528489

2528490

2528491

2528492

2528493

2528494

2528495

2528496

2528497

2528499

40776_at

8048541

A_23_P90710

A_33_P3275801

GE81087

GO:0003012

GO:0005198

GO:0005200

GO:0005515

GO:0005634

GO:0005635

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0005886

GO:0005911

GO:0005916

GO:0006936

GO:0006998

GO:0007010

GO:0008016

GO:0008092

GO:0014704

GO:0030018

GO:0031594

GO:0042383

GO:0042802

GO:0043226

GO:0043292

GO:0045109

GO:0045111

GO:0048856

GO:0051286

GO:0060538

GO:0061024

GO:0070062

GO:0097512

HMNXSV003010493

Hs.171185.1.S1_3p_s_at

ILMN_1698995

M63391_rna1_at

PH_hs_0032457

TC02001326.hg

g4503306_3p_s_at

Participates

as a component of

Z Disk Complex [cytosol] (Homo sapiens)

Inferred To

Des [cytosol] (Mus musculus)

Des [cytosol] (Rattus norvegicus)

Homologues of DES [cytosol] (Canis familiaris)

DES [cytosol] (Bos taurus)

DES [cytosol] (Canis familiaris)

DES [cytosol] (Gallus gallus)

DES [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000363071, ENST00000373960

OpenTargets

ENSG00000175084

HPA

ENSG00000175084-DES

PRO

P17661

Pharos - Targets

P17661

GlyGen

P17661

Orphanet

DES

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.831	8
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.818	8
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.782	8
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.718	6
UniProt:Q13496 MTM1	1	MTM1 [cytosol] (R-HSA-1604646)	0.711	13
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.602	6
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:O75923 DYSF	1	DYSF [cytoplasmic vesicle membrane] (R-HSA-5263626)	0.505	3
UniProt:Q9UBX2 DUX4	1	DUX4 [nucleoplasm] (R-HSA-9816412)	0.471	3

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