Reactome | CHRM1 [plasma membrane]

CHRM1 [plasma membrane]

Stable Identifier

R-HSA-390628

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

M1, Muscarinic acetylcholine receptor M1, ACM1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:CHRM1,3,5 antagonists [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 bind acetylcholine (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11229 CHRM1

Gene Names

CHRM1

Chain

chain:1-460

Reference Genes

BioGPS Gene:1128 CHRM1

COSMIC (genes):CHRM1 CHRM1

CTD Gene:1128 CHRM1

dbSNP Gene:1128 CHRM1

ENSEMBL:ENSG00000168539 CHRM1

ENSEMBL_homo_sapiens_GENE:ENSG00000168539.4 CHRM1

HGNC:1950 CHRM1

KEGG Gene (Homo sapiens):1128 CHRM1

Monarch:1128 CHRM1

NCBI Gene:1128 CHRM1

OMIM:118510 CHRM1

UCSC:P11229 CHRM1

Reference Transcript

Other Identifiers

1128

11727798_at

11727799_at

16739648

231783_PM_at

231783_at

3376318

3376319

3376320

3376321

3376322

3376323

3376325

7948912

80873_at

A_24_P415615

A_33_P3367860

GE62855

GE80945

GO:0003824

GO:0004435

GO:0004930

GO:0004993

GO:0005515

GO:0005886

GO:0006886

GO:0007165

GO:0007186

GO:0007187

GO:0007197

GO:0007205

GO:0007207

GO:0007213

GO:0007268

GO:0007274

GO:0007399

GO:0016020

GO:0016787

GO:0016907

GO:0022600

GO:0023052

GO:0030054

GO:0030154

GO:0030425

GO:0032279

GO:0040012

GO:0042734

GO:0043226

GO:0043270

GO:0043679

GO:0045202

GO:0045211

GO:0046541

GO:0048856

GO:0050877

GO:0050890

GO:0060078

GO:0060089

GO:0060251

GO:0090316

GO:0095500

GO:0097060

GO:0098664

GO:0098685

GO:0098839

GO:0098978

GO:0098981

GO:0099170

HMNXSV003030054

Hs.247917.0.S2_3p_at

ILMN_1751689

M35128_at

PH_hs_0029494

TC11001885.hg

Participates

as a member of

CHRM1,3,5 [plasma membrane] (Homo sapiens)

Inferred To

gar-3 [plasma membrane] (Caenorhabditis elegans)

CHRM1 [plasma membrane] (Bos taurus)

CHRM1 [plasma membrane] (Canis familiaris)

CHRM1 [plasma membrane] (Sus scrofa)

Chrm1 [plasma membrane] (Mus musculus)

Chrm1 [plasma membrane] (Rattus norvegicus)

chrm1 [plasma membrane] (Xenopus tropicalis)

mAChR-A [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_000729.2, XP_011543044.1

ZINC - World Drugs

ACM1_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000168539

ZINC - FDA approved

ACM1_HUMAN

ZINC - Substances

ACM1_HUMAN

ZINC target

P11229

ZINC - Biogenic

ACM1_HUMAN

PRO

P11229

PDB

6WJC, 6ZFZ, 6ZG4, 5CXV, 6ZG9, 6OIJ

ZINC - Investigational

ACM1_HUMAN

ZINC - Metabolites

ACM1_HUMAN

HPA

ENSG00000168539-CHRM1

GeneCards

P11229

Ensembl

ENST00000306960, ENSP00000306490, ENST00000543973, ENSG00000168539, ENSP00000441188

Pharos - Targets

P11229

ZINC - Predictions - Purchasable

ACM1_HUMAN

HMDB Protein

HMDBP10809