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ADRB1 [plasma membrane]
Stable Identifier
R-HSA-390653
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Beta-1 adrenoceptor, RecName: Full=Beta-1 adrenergic receptor; AltName: Full=Beta-1 adrenoreceptor; Short=Beta-1 adrenoceptor;
GN Name=ADRB1; Synonyms=ADRB1R, B1AR;
OS Homo sapiens, ADRB1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADRB1:ADR,NAd [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADRB1:ADR,NAd [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADRB1:ADR,NAd [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADRB1:ADR,NAd [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADRB1:ADR,NAd [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Adrenoceptors (Homo sapiens)
ADRB1 bind ADR,NAd (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
ADRB1,2,3:β-blockers [plasma membrane] (Homo sapiens)
ADRB1,2,3 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
ADRB1:ADR,NAd [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β1,2-agonists:ADBR1,2 [plasma membrane] (Homo sapiens)
ADRB1,2 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β1-agonists:ADBR1 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
ADRB2 bind ADR,NAd (Homo sapiens)
ADRB1,2,3:β-blockers [plasma membrane] (Homo sapiens)
ADRB1,2,3 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β1,2-agonists:ADBR1,2 [plasma membrane] (Homo sapiens)
ADRB1,2 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
ADRB3 bind ADR,NAd (Homo sapiens)
ADRB1,2,3:β-blockers [plasma membrane] (Homo sapiens)
ADRB1,2,3 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β-blockers bind ADRB1,2,3 (Homo sapiens)
ADRB1,2,3 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
ADRB1,2,3:β-blockers [plasma membrane] (Homo sapiens)
ADRB1,2,3 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β1,2-agonists bind ADRB1,2 (Homo sapiens)
ADRB1,2 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β1,2-agonists:ADBR1,2 [plasma membrane] (Homo sapiens)
ADRB1,2 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β1-agonists bind ADRB1 (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
β1-agonists:ADBR1 [plasma membrane] (Homo sapiens)
ADRB1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08588 ADRB1
Gene Names
ADRB1, ADRB1R, B1AR
Chain
chain:1-477
Reference Genes
BioGPS Gene:153 ADRB1
COSMIC (genes):ADRB1 ADRB1
CTD Gene:153 ADRB1
dbSNP Gene:153 ADRB1
ENSEMBL:ENSG00000043591 ADRB1
HGNC:285 ADRB1
KEGG:hsa:153 ADRB1
Monarch:153 ADRB1
NCBI Gene:153 ADRB1
OMIM:109630 ADRB1
UCSC:P08588 ADRB1
Reference Transcript
RefSeq:NM_000684.2 ADRB1
Other Identifiers
11729003_at
11729004_at
153
16709453
208214_PM_at
208214_at
229309_PM_at
229309_at
31550_at
3265108
3265109
3265110
3265141
3265142
3265143
3265144
3265145
3265146
3265147
3265148
3265149
45148_at
7930627
A_14_P110345
A_23_P52240
A_33_P3310189
GE631286
GE88245
GO:0001996
GO:0001997
GO:0002024
GO:0002025
GO:0003013
GO:0004930
GO:0004935
GO:0004939
GO:0004940
GO:0005515
GO:0005768
GO:0005769
GO:0005886
GO:0007186
GO:0007189
GO:0009409
GO:0016020
GO:0030154
GO:0030165
GO:0031410
GO:0031649
GO:0031694
GO:0040015
GO:0042596
GO:0043226
GO:0043410
GO:0045187
GO:0045823
GO:0046982
GO:0050873
GO:0060078
GO:0060089
GO:0071880
GO:0098685
GO:0098992
GO:0099579
GO:0120162
HMNXSV003041757
Hs.37744.0.S1_3p_at
ILMN_1804255
PH_hs_0005582
TC10000829.hg
TC10002305.hg
g4557264_3p_at
Participates
as an input of
β1-agonists bind ADRB1 (Homo sapiens)
ADRB1 bind ADR,NAd (Homo sapiens)
as a member of
ADRB1,2 [plasma membrane] (Homo sapiens)
ADRB1,2,3 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
as a component of
β1-agonists:ADBR1 [plasma membrane] (Homo sapiens)
ADRB1:ADR,NAd [plasma membrane] (Homo sapiens)
Inferred To
adrb1 [plasma membrane]
(Danio rerio)
ADRB1 [plasma membrane]
(Bos taurus)
ADRB1 [plasma membrane]
(Gallus gallus)
ADRB1 [plasma membrane]
(Sus scrofa)
Adrb1 [plasma membrane]
(Mus musculus)
Adrb1 [plasma membrane]
(Rattus norvegicus)
LOC116412276 [plasma membrane]
(Xenopus tropicalis)
Homologues of ADRB1 [plasma membrane]
(Drosophila melanogaster)
Octbeta1R [plasma membrane]
(Drosophila melanogaster)
Octbeta2R [plasma membrane]
(Drosophila melanogaster)
Octbeta3R [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000675.1
ZINC - World Drugs
ADRB1_HUMAN
Guide to Pharmacology - Targets
28
ENSEMBL
ENST00000369295
,
ENSP00000358301
OpenTargets
ENSG00000043591
ZINC - FDA approved
ADRB1_HUMAN
ZINC - Substances
ADRB1_HUMAN
ZINC - Biogenic
ADRB1_HUMAN
ZINC target
P08588
PRO
P08588
GlyGen
P08588
PDB
7BU7
,
7BU6
,
2LSQ
,
7BTS
,
7BVQ
ZINC - Investigational
ADRB1_HUMAN
ZINC - Metabolites
ADRB1_HUMAN
HPA
ENSG00000043591-ADRB1
Pharos - Targets
P08588
ZINC - Predictions - Purchasable
ADRB1_HUMAN
HMDB Protein
HMDBP01632
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86UL8 MAGI2
1
MAGI2 [cytosol]
(R-HSA-451399)
0.776
8
UniProt:Q5TCQ9 MAGI3
0.655
5
UniProt:P31016 Dlg4
3
Dlg4 [plasma membrane]
(R-RNO-9612601)
Dlg4 [endocytic vesicle membrane]
(R-RNO-416847)
Dlg4 [cytosol]
(R-RNO-6794248)
0.623
2
UniProt:P30542 ADORA1
1
ADORA1 [plasma membrane]
(R-HSA-418941)
0.61
5
UniProt:P21917 DRD4
1
DRD4 [plasma membrane]
(R-HSA-390809)
0.471
2
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