Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ADRA2C [plasma membrane]
Stable Identifier
R-HSA-390662
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha-2C adrenoceptor, RecName: Full=Alpha-2C adrenergic receptor; AltName: Full=Alpha-2C adrenoreceptor; AltName: Full=Alpha-2C adrenoceptor; AltName: Full=Alpha-2 adrenergic receptor subtype C4;
GN Name=ADRA2C; Synonyms=ADRA2L2, ADRA2RL2;
OS Homo sapiens, ADA2C_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Adrenaline signalling through Alpha-2 adrenergic receptor (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Adrenaline,noradrenaline inhibits insulin secretion (Homo sapiens)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gz complex dissociates (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Adrenoceptors (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
α2-agonists bind ADRA2A,B,C (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
α2-agonists:ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18825 ADRA2C
Gene Names
ADRA2C, ADRA2L2, ADRA2RL2
Chain
chain:1-462
Reference Genes
BioGPS Gene:152 ADRA2C
COSMIC (genes):ADRA2C ADRA2C
CTD Gene:152 ADRA2C
dbSNP Gene:152 ADRA2C
ENSEMBL:ENSG00000184160 ADRA2C
ENSEMBL_homo_sapiens_GENE:ENSG00000184160.8 ADRA2C
HGNC:283 ADRA2C
KEGG Gene (Homo sapiens):152 ADRA2C
Monarch:152 ADRA2C
NCBI Gene:152 ADRA2C
Reference Transcript
RefSeq:NM_000683.3 ADRA2C
Other Identifiers
11728580_x_at
11756359_s_at
152
16964516
206128_PM_at
206128_at
2716330
2716331
2716332
2716333
2716334
2716335
2716336
2716337
2716338
2716339
2716340
2716341
34512_at
8093826
A_14_P111386
A_23_P256158
GE57492
GO:0003012
GO:0003013
GO:0004930
GO:0004935
GO:0004938
GO:0005515
GO:0005737
GO:0005768
GO:0005886
GO:0006940
GO:0007165
GO:0007186
GO:0007267
GO:0010700
GO:0016020
GO:0019229
GO:0023052
GO:0030154
GO:0030168
GO:0031410
GO:0031694
GO:0032148
GO:0032811
GO:0035624
GO:0036211
GO:0042060
GO:0042803
GO:0043226
GO:0043410
GO:0045666
GO:0046982
GO:0048856
GO:0051379
GO:0060089
GO:0071875
GO:0071880
HMNXSV003015120
Hs.123022.0.S2_3p_at
ILMN_1733963
PH_hs_0027798
TC04000052.hg
U72648_s_at
Participates
as a member of
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
Inferred To
tyra-2 [plasma membrane]
(Caenorhabditis elegans)
Oct-TyrR [plasma membrane]
(Drosophila melanogaster)
Octalpha2R [plasma membrane]
(Drosophila melanogaster)
ADRA2C [plasma membrane]
(Bos taurus)
ADRA2C [plasma membrane]
(Canis familiaris)
ADRA2C [plasma membrane]
(Gallus gallus)
ADRA2C [plasma membrane]
(Sus scrofa)
Homologues of ADRA2C [plasma membrane]
(Caenorhabditis elegans)
Homologues of ADRA2C [plasma membrane]
(Drosophila melanogaster)
ser-2 [plasma membrane]
(Caenorhabditis elegans)
adra2c [plasma membrane]
(Danio rerio)
adra2c [plasma membrane]
(Xenopus tropicalis)
Adra2c [plasma membrane]
(Mus musculus)
Adra2c [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000674.2
ZINC - World Drugs
ADA2C_HUMAN
Guide to Pharmacology - Targets
27
OpenTargets
ENSG00000184160
ZINC - FDA approved
ADA2C_HUMAN
ZINC - Substances
ADA2C_HUMAN
ZINC - Biogenic
ADA2C_HUMAN
ZINC target
P18825
PRO
P18825
PDB
6KUW
ZINC - Investigational
ADA2C_HUMAN
ZINC - Metabolites
ADA2C_HUMAN
GeneCards
P18825
HPA
ENSG00000184160-ADRA2C
Ensembl
ENSP00000386069
,
ENST00000330055
,
ENSG00000184160
Pharos - Targets
P18825
ZINC - Predictions - Purchasable
ADA2C_HUMAN
HMDB Protein
HMDBP10771
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text