Reactome | MYL9 [cytosol]

MYL9 [cytosol]

Stable Identifier

R-HSA-390753

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin regulatory light polypeptide 9, MYL9_HUMAN, LC20, MLC2

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 regulatory light chains [cytosol] (Homo sapiens)
        
        MYL9 [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 regulatory light chains [cytosol] (Homo sapiens)
        
        MYL9 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
        
        MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)
        
        MYL9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24844 MYL9

Gene Names

MYL9, MLC2, MRLC1, MYRL2

Chain

initiator methionine:1, chain:2-172

Reference Genes

BioGPS Gene:10398 MYL9

COSMIC (genes):MYL9 MYL9

CTD Gene:10398 MYL9

dbSNP Gene:10398 MYL9

ENSEMBL:ENSG00000101335 MYL9

HGNC:15754 MYL9

KEGG Gene (Homo sapiens):10398 MYL9

Monarch:10398 MYL9

NCBI Gene:10398 MYL9

OMIM:609905 MYL9

UCSC:P24844 MYL9

Reference Transcript

Other Identifiers

0002450047

0003870520

0104780193

10398

11715588_x_at

11754084_x_at

16913341

201058_3p_s_at

201058_s_at

244149_at

3883922

3883925

3883926

3883929

3883930

3883931

3883932

3883934

39145_at

78579_at

8062312

A_23_P210425

GE504952

GE853282

GO:0001725

GO:0002376

GO:0003674

GO:0005198

GO:0005509

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005859

GO:0005938

GO:0006936

GO:0006937

GO:0006950

GO:0007155

GO:0008092

GO:0008150

GO:0008307

GO:0016459

GO:0016460

GO:0030018

GO:0030154

GO:0032036

GO:0032991

GO:0043167

GO:0043226

GO:0045652

GO:0046872

GO:0048856

GO:0070527

Hs.134192.0.A1_3p_at

ILMN_1675062

ILMN_1776953

ILMN_1843862

J02854_at

PH_hs_0008070

PH_hs_0025293

TC20000268.hg

TC20001202.hg

TC20001203.hg

Participates

as a member of

as an output of

MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)

Other forms of this molecule

p-S20-MYL9 [cytosol]

p-T19-MYL9 [cytosol]

p-T19,S20-MYL9 [cytosol]

Inferred To

Mlc2 [cytosol] (Drosophila melanogaster)

CT39356 [cytosol] (Drosophila melanogaster)

mlc-4 [cytosol] (Caenorhabditis elegans)

MYL9 [cytosol] (Bos taurus)

MYL9 [cytosol] (Canis familiaris)

MYL9 [cytosol] (Gallus gallus)

MYL9 [cytosol] (Plasmodium falciparum)

MYL9 [cytosol] (Sus scrofa)

MYL9 [cytosol] (Xenopus tropicalis)

rlc1 [cytosol] (Schizosaccharomyces pombe)

myl9b [cytosol] (Danio rerio)

mlcR [cytosol] (Dictyostelium discoideum)

mlc-1 [cytosol] (Caenorhabditis elegans)

MLC2 [cytosol] (Saccharomyces cerevisiae)

Homologues of MYL9 [cytosol] (Caenorhabditis elegans)

Homologues of MYL9 [cytosol] (Drosophila melanogaster)

mlc-2 [cytosol] (Caenorhabditis elegans)

sqh [cytosol] (Drosophila melanogaster)

Myl9 [cytosol] (Mus musculus)

Myl9 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_006088.2, NP_852667.1

OpenTargets

ENSG00000101335

HPA

ENSG00000101335-MYL9

GeneCards

P24844

Ensembl

ENST00000279022, ENST00000346786, ENSP00000217313, ENSP00000279022, ENSG00000101335

PRO

P24844

Pharos - Targets

P24844

HMDB Protein

HMDBP07826

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A2AST1 A2AST1			0.463	2