Reactome | DRD4 [plasma membrane]

DRD4 [plasma membrane]

Stable Identifier

R-HSA-390809

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dopamine receptor 4, RecName: Full=D, DRD4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Dopamine receptors (Homo sapiens)
        
        D2D3,4 bind to DA (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)
        
        DRD3,4:DA [plasma membrane] (Homo sapiens)
        
        DRD3,4 [plasma membrane] (Homo sapiens)
        
        DRD4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21917 DRD4

Gene Names

DRD4

Chain

chain:1-419

Reference Genes

BioGPS Gene:1815 DRD4

COSMIC (genes):DRD4 DRD4

CTD Gene:1815 DRD4

dbSNP Gene:1815 DRD4

ENSEMBL:ENSG00000069696 DRD4

ENSEMBL:ENSG00000069696.7 DRD4

ENSEMBL:ENSG00000276825.2 DRD4

HGNC:3025 DRD4

KEGG Gene (Homo sapiens):1815 DRD4

Monarch:1815 DRD4

NCBI Gene:1815 DRD4

OMIM:126452 DRD4

UCSC:P21917 DRD4

Reference Transcript

RefSeq:NM_000797.3 DRD4

Other Identifiers

11742292_a_at

16720258

1815

208215_PM_x_at

208215_x_at

3316059

3316060

3316061

3316062

3316065

3316067

3316068

3316069

3316070

3316071

3316072

3316073

35042_at

7937433

A_23_P150162

A_24_P25668

A_33_P3373765

GE57616

GO:0001591

GO:0001662

GO:0001963

GO:0001975

GO:0004930

GO:0004952

GO:0004993

GO:0005515

GO:0005813

GO:0005815

GO:0005856

GO:0005886

GO:0006874

GO:0007165

GO:0007186

GO:0007187

GO:0007195

GO:0007198

GO:0007212

GO:0007268

GO:0008344

GO:0015459

GO:0016020

GO:0016192

GO:0017124

GO:0023052

GO:0030425

GO:0030594

GO:0032417

GO:0033674

GO:0034776

GO:0035176

GO:0035240

GO:0036211

GO:0042053

GO:0042417

GO:0042596

GO:0042752

GO:0042802

GO:0043226

GO:0043406

GO:0046872

GO:0048148

GO:0048149

GO:0048511

GO:0050482

GO:0050709

GO:0050877

GO:0051378

GO:0051379

GO:0051380

GO:0051586

GO:0055065

GO:0055085

GO:0060080

GO:0060089

GO:0098772

GO:0098794

GO:0098978

GO:0099149

GO:1901386

HMNXSV003015851

ILMN_2112915

PH_hs_0022242

S76942_s_at

TC11000023.hg

TC11002490.hg

TC11002491.hg

g4503388_3p_at

g4503388_3p_x_at

Participates

as a member of

DRD3,4 [plasma membrane] (Homo sapiens)

Inferred To

Drd4c [plasma membrane] (Danio rerio)

Homologues of DRD4 [plasma membrane] (Drosophila melanogaster)

5-HT1B [plasma membrane] (Drosophila melanogaster)

5-HT1A [plasma membrane] (Drosophila melanogaster)

DRD4 [plasma membrane] (Gallus gallus)

DRD4 [plasma membrane] (Mus musculus)

DRD4 [plasma membrane] (Rattus norvegicus)

DRD4 [plasma membrane] (Sus scrofa)

ser-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000788.2

ZINC - World Drugs

DRD4_HUMAN

Guide to Pharmacology - Targets

217

OpenTargets

ENSG00000069696

ZINC - FDA approved

DRD4_HUMAN

ZINC - Substances

DRD4_HUMAN

ZINC - Biogenic

DRD4_HUMAN

ZINC target

P21917

PRO

P21917

PDB

5WIV, 5WIU

ZINC - Investigational

DRD4_HUMAN

ZINC - Metabolites

DRD4_HUMAN

GeneCards

P21917

HPA

ENSG00000069696-DRD4

Ensembl

ENSP00000478431, ENSP00000176183, ENSG00000276825, ENSG00000069696, ENST00000611962, ENST00000176183

Pharos - Targets

P21917

ZINC - Predictions - Purchasable

DRD4_HUMAN

HMDB Protein

HMDBP02531

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.556	3
UniProt:P17677 GAP43	2	GAP43 [plasma membrane] (R-HSA-452888) PALM-C3,4-GAP43 [plasma membrane] (R-HSA-8933482)	0.556	3
UniProt:P08588 ADRB1	1	ADRB1 [plasma membrane] (R-HSA-390653)	0.471	2