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FYB [cytosol]
Stable Identifier
R-HSA-390925
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ADAP, FYN-binding protein, SLAP-130
Locations in the PathwayBrowser for interactor UniProt:Q13094 LCP2
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)
FYB [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
p-SLP-76 binds ADAP (Homo sapiens)
FYB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15117 FYB
Gene Names
FYB, SLAP130, FYB1
Chain
chain:1-783
Reference Genes
BioGPS Gene:2533 FYB
CTD Gene:2533 FYB
dbSNP Gene:2533 FYB
ENSEMBL:ENSG00000082074 FYB
ENSEMBL_homo_sapiens_GENE:ENSG00000082074.19 FYB
HGNC:4036 FYB
KEGG Gene (Homo sapiens):2533 FYB
Monarch:2533 FYB
NCBI Gene:2533 FYB
OMIM:602731 FYB
UCSC:O15117 FYB
Reference Transcript
RefSeq:XM_006714466.2 FYB
RefSeq:XM_011514009.1 FYB
RefSeq:NM_001243093.1 FYB
RefSeq:NM_199335.3 FYB
RefSeq:XM_006714465.2 FYB
RefSeq:XM_011514008.2 FYB
RefSeq:NM_001465.4 FYB
RefSeq:XM_006714464.2 FYB
RefSeq:XM_011514010.1 FYB
Other Identifiers
11724004_a_at
11724005_s_at
11730372_a_at
11730373_a_at
11730374_a_at
16995601
205285_PM_s_at
205285_s_at
211794_PM_at
211794_at
211795_PM_s_at
211795_s_at
227266_PM_s_at
227266_s_at
2533
2854328
2854329
2854330
2854332
2854333
2854335
2854336
2854338
2854340
2854343
2854345
2854349
2854355
2854368
2854369
2854370
2854371
2854385
2854407
41819_at
55978_at
61712_at
74675_s_at
8111739
A_23_P122127
A_24_P393740
GE81027
GO:0002376
GO:0005102
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006955
GO:0007229
GO:0008150
GO:0008289
GO:0015629
GO:0023052
GO:0032991
GO:0043226
GO:0044877
GO:0050852
GO:0070161
GO:0072659
HMNXSV003038047
Hs.34192.1.A1_3p_at
Hs.58435.0.S1_3p_a_at
ILMN_1796537
ILMN_2280548
PH_hs_0023383
TC05001295.hg
TC05002968.hg
U93049_at
g7416992_3p_a_at
Participates
as a component of
p-Y429,Y453,Y470,Y496y-SIRPA:CD47:SKAP2:FYB [plasma membrane] (Homo sapiens)
p-SLP-76:ADAP [cytosol] (Homo sapiens)
as an input of
p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)
p-SLP-76 binds ADAP (Homo sapiens)
Inferred To
FYB [cytosol]
(Bos taurus)
si:ch211-188c16.1 [cytosol]
(Danio rerio)
FYB1 [cytosol]
(Canis familiaris)
FYB1 [cytosol]
(Gallus gallus)
FYB1 [cytosol]
(Sus scrofa)
fyb1 [cytosol]
(Xenopus tropicalis)
Fyb1 [cytosol]
(Mus musculus)
Fyb1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_011512312.1
,
XP_011512310.1
,
NP_955367.1
,
NP_001456.3
,
XP_006714528.1
,
NP_001230022.1
,
XP_011512311.1
,
XP_006714527.1
,
XP_006714529.1
HPA
ENSG00000082074-FYB1
GeneCards
O15117
Ensembl
ENSP00000426346
,
ENST00000515010
,
ENSG00000082074
,
ENSP00000425845
,
ENSP00000493623
,
ENST00000351578
,
ENST00000646045
,
ENST00000512982
,
ENSP00000316460
PRO
O15117
Pharos - Targets
O15117
Orphanet
25600
PDB
1RI9
,
2GTJ
,
2GTO
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.904
11
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.819
7
UniProt:Q86WV1 SKAP1
0.729
6
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.621
3
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.564
3
UniProt:O60880 SH2D1A
1
SH2D1A [cytosol]
(R-HSA-5685108)
0.527
2
UniProt:P06241-3 FYN
0.488
2
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