Reactome | SKAP2 [cytosol]

SKAP2 [cytosol]

Stable Identifier

R-HSA-390927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Src kinase-associated phosphoprotein 2 (SCAP2), SKAP2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y2R2 PTPN22

Expand all

External Reference Information

External Reference

UniProt:O75563 SKAP2

Gene Names

SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R

Chain

chain:1-359

Reference Genes

BioGPS Gene:8935 SKAP2

COSMIC (genes):SKAP2 SKAP2

CTD Gene:8935 SKAP2

dbSNP Gene:8935 SKAP2

ENSEMBL:ENSG00000005020 SKAP2

ENSEMBL_homo_sapiens_GENE:ENSG00000005020.13 SKAP2

HGNC:15687 SKAP2

KEGG Gene (Homo sapiens):8935 SKAP2

Monarch:8935 SKAP2

NCBI Gene:8935 SKAP2

OMIM:605215 SKAP2

UCSC:O75563 SKAP2

Reference Transcript

Other Identifiers

11720044_at

11749275_a_at

11758114_x_at

17056072

204361_PM_s_at

204361_s_at

204362_PM_at

204362_at

216899_PM_s_at

216899_s_at

225639_PM_at

225639_at

3042629

3042630

3042631

3042632

3042634

3042642

3042644

3042649

3042650

3042653

3042656

3042657

3042668

3042673

3042676

3042677

3042678

36091_at

64467_at

8138689

8935

A_23_P157128

A_33_P3388312

GE54436

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0007165

GO:0008285

GO:0023052

GO:0042113

GO:0043226

HMNXSV003011544

HMNXSV003014482

Hs.52644.1.S1_3p_a_at

Hs.5888.0.A1_3p_at

ILMN_1657129

ILMN_2125010

PH_hs_0030091

TC07001217.hg

g4506962_3p_at

g4506962_3p_x_at

Participates

as a component of

p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)

as an input of

p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)

Inferred To

SKAP2 [cytosol] (Bos taurus)

SKAP2 [cytosol] (Canis familiaris)

SKAP2 [cytosol] (Gallus gallus)

SKAP2 [cytosol] (Sus scrofa)

Skap2 [cytosol] (Mus musculus)

Skap2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001290397.1, NP_003921.2, XP_016868260.1

OpenTargets

ENSG00000005020

GeneCards

O75563

HPA

ENSG00000005020-SKAP2

Ensembl

ENSP00000005587, ENST00000345317, ENSG00000005020

PRO

O75563

Pharos - Targets

O75563

PDB

3OMH

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.611	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.547	2
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.527	2
UniProt:Q8N878 FRMD1			0.527	2
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.508	2

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