Reactome | PTK2B [cytosol]

PTK2B [cytosol]

Stable Identifier

R-HSA-390932

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein tyrosine kinase 2 beta (PYK2), Focal adhesion kinase 2 (FADK2)

Locations in the PathwayBrowser for interactor UniProt:Q9Y6R4 M3K4

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin-2 signaling (Homo sapiens)
        
        PTK2B binds JAK3 (Homo sapiens)
        
        PTK2B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14289 PTK2B

Gene Names

PTK2B, FAK2, PYK2, RAFTK

Chain

chain:1-1009

Reference Genes

BioGPS Gene:2185 PTK2B

COSMIC (genes):PTK2B PTK2B

CTD Gene:2185 PTK2B

dbSNP Gene:2185 PTK2B

ENSEMBL:ENSG00000120899 PTK2B

HGNC:9612 PTK2B

KEGG:hsa:2185 PTK2B

Monarch:2185 PTK2B

NCBI Gene:2185 PTK2B

OMIM:601212 PTK2B

UCSC:Q14289 PTK2B

Reference Transcript

Other Identifiers

11720980_a_at

11720981_a_at

11720982_s_at

17067231

2009_at

203110_PM_at

203110_at

203111_PM_s_at

203111_s_at

2185

3091302

3091303

3091304

3091305

3091306

3091307

3091308

3091310

3091312

3091313

3091314

3091315

3091319

3091320

3091321

3091322

3091324

3091325

3091326

3091327

3091328

3091329

3091330

3091331

3091332

3091333

3091334

3091335

3091336

3091337

3091338

3091340

3091341

3091342

3091343

3091344

3091345

3091346

3091347

3091348

3091349

3091350

3091352

3091354

3091355

3091357

3091360

3091362

3091363

3091364

3091365

3091366

3091367

3091368

3091369

3091372

3091373

33804_at

8145490

A_14_P128594

A_23_P168836

A_33_P3273000

A_33_P3351536

GE576628

GE59167

GE81349

GO:0000165

GO:0000302

GO:0001525

GO:0001556

GO:0001666

GO:0001934

GO:0001954

GO:0002040

GO:0002250

GO:0002315

GO:0002376

GO:0002931

GO:0003824

GO:0004672

GO:0004683

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006468

GO:0006915

GO:0006968

GO:0007010

GO:0007015

GO:0007155

GO:0007165

GO:0007166

GO:0007172

GO:0007173

GO:0007204

GO:0007229

GO:0008284

GO:0008285

GO:0008360

GO:0009410

GO:0009612

GO:0009725

GO:0009749

GO:0010595

GO:0010656

GO:0010758

GO:0010976

GO:0012501

GO:0014009

GO:0014069

GO:0016740

GO:0017146

GO:0018108

GO:0019899

GO:0022414

GO:0030027

GO:0030054

GO:0030154

GO:0030155

GO:0030279

GO:0030307

GO:0030335

GO:0030424

GO:0030425

GO:0030426

GO:0030502

GO:0030838

GO:0030865

GO:0031175

GO:0031625

GO:0032956

GO:0033209

GO:0034330

GO:0035235

GO:0035254

GO:0035902

GO:0038083

GO:0042220

GO:0042542

GO:0042976

GO:0042995

GO:0043025

GO:0043066

GO:0043149

GO:0043157

GO:0043197

GO:0043226

GO:0043267

GO:0043423

GO:0043524

GO:0043534

GO:0044297

GO:0044877

GO:0045429

GO:0045453

GO:0045471

GO:0045638

GO:0045727

GO:0045766

GO:0045860

GO:0046330

GO:0046777

GO:0048010

GO:0048041

GO:0048167

GO:0048471

GO:0048870

GO:0051128

GO:0051239

GO:0051247

GO:0051279

GO:0051591

GO:0051592

GO:0051897

GO:0051968

GO:0060291

GO:0060292

GO:0065003

GO:0065008

GO:0070098

GO:0070161

GO:0070374

GO:0071300

GO:0071498

GO:0086100

GO:0097440

GO:0098685

GO:0098772

GO:0098793

GO:0098794

GO:0098978

GO:0099092

GO:0099151

GO:0099170

GO:0099602

GO:0140096

GO:1902531

GO:2000058

GO:2000060

GO:2000379

GO:2000463

GO:2000538

GO:2000573

HMNXSV003006909

HMNXSV003026497

ILMN_1732318

ILMN_1765189

ILMN_2330966

PH_hs_0024653

TC08000207.hg

TC08001850.hg

U43522_at

g1165218_3p_at

g1165218_3p_x_at

g4758975_3p_a_at

Participates

as a member of

RHOU effectors [cytosol] (Homo sapiens)

as a component of

as an input of

Other forms of this molecule

PTK2B [cytosol]

p-Y-PTK2B [cytosol]

Inferred To

Ghost homologue of PTK2B [cytosol] (Xenopus tropicalis)

PTK2B [cytosol] (Bos taurus)

PTK2B [cytosol] (Caenorhabditis elegans)

PTK2B [cytosol] (Canis familiaris)

PTK2B [cytosol] (Danio rerio)

PTK2B [cytosol] (Gallus gallus)

PTK2B [cytosol] (Mus musculus)

PTK2B [cytosol] (Rattus norvegicus)

PTK2B [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016868703.1, NP_775267.1, NP_775266.1, NP_775268.1, XP_005273504.1, XP_011542743.1, NP_004094.3

ZINC - World Drugs

FAK2_HUMAN

Guide to Pharmacology - Targets

2181

OpenTargets

ENSG00000120899

ENSEMBL

ENSP00000380638, ENSP00000332816, ENST00000346049, ENST00000397501, ENST00000420218, ENST00000517339, ENSP00000427931, ENSP00000391995

ZINC - FDA approved

FAK2_HUMAN

ZINC - Substances

FAK2_HUMAN

ZINC - Biogenic

FAK2_HUMAN

ZINC target

Q14289

PRO

Q14289

GlyGen

Q14289

PDB

2LK4, 3FZR, 3H3C, 3FZP, 3FZO, 7PLL, 3GM2, 3U3F, 3GM3, 3FZT, 3FZS, 3GM1, 4XEF, 4XEK, 4H1M, 8YGX, 4R32, 6LF3, 5TO8, 3CC6, 4EKU, 4XEV, 3ET7, 5TOB, 4H1J, 8XOX

ZINC - Investigational

FAK2_HUMAN

HPA

ENSG00000120899-PTK2B

Pharos - Targets

Q14289

ZINC - Predictions - Purchasable

FAK2_HUMAN

HMDB Protein

HMDBP01425

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.702	5
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.643	3
UniProt:Q7L0Q8 RHOU	4	p-Y254-RHOU [endosome membrane] (R-HSA-9726860) p-Y254-RHOU [plasma membrane] (R-HSA-9726857) RHOU [plasma membrane] (R-HSA-194914) RHOU [cytosol] (R-HSA-194901)	0.581	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.527	4
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.527	2
UniProt:O43294 TGFI1			0.527	2
UniProt:Q9Y6R4 M3K4			0.463	2
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.462	2