Reactome | HTR1A [plasma membrane]

HTR1A [plasma membrane]

Stable Identifier

R-HSA-390971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5-HT1A receptor, RecName: Full=5-hydroxytryptamine receptor 1A; Short=5-HT-1A; Short=5-HT1A; AltName: Full=Serotonin receptor 1A; AltName: Full=G-21;
GN Name=HTR1A; Synonyms=ADRB2RL1, ADRBRL1;
OS Homo sapiens, 5HT1A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08908 HTR1A

Gene Names

HTR1A, ADRB2RL1, ADRBRL1

Chain

chain:1-422

Reference Genes

BioGPS Gene:3350 HTR1A

COSMIC (genes):HTR1A HTR1A

CTD Gene:3350 HTR1A

dbSNP Gene:3350 HTR1A

ENSEMBL:ENSG00000178394 HTR1A

HGNC:5286 HTR1A

KEGG:hsa:3350 HTR1A

Monarch:3350 HTR1A

NCBI Gene:3350 HTR1A

OMIM:109760 HTR1A

UCSC:P08908 HTR1A

Reference Transcript

RefSeq:NM_000524.3 HTR1A

Other Identifiers

11741081_a_at

11741082_at

16996667

16996670

221351_PM_at

221351_at

236714_PM_at

236714_at

2859388

2859389

2859390

2859391

2859392

2859393

2859394

2859395

2859396

2859397

2859398

3350

47305_at

8112333

ADDON002886.hg

A_24_P97687

GE547469

GE554019

GO:0001586

GO:0001662

GO:0003013

GO:0004930

GO:0004993

GO:0005515

GO:0005886

GO:0007186

GO:0007187

GO:0007198

GO:0007210

GO:0007214

GO:0007268

GO:0008284

GO:0014062

GO:0016020

GO:0019229

GO:0023052

GO:0030425

GO:0030594

GO:0035640

GO:0042053

GO:0042428

GO:0042995

GO:0045202

GO:0046883

GO:0050795

GO:0051378

GO:0060089

GO:0090722

GO:0098664

GO:0099589

HMNXSV003031338

HMNXSV003052920

Hs.56400.0.A1_3p_at

Hs.56400.0.A1_3p_x_at

ILMN_1813690

M83181_at

TC05001404.hg

g4504530_3p_at

p13190

Participates

as a component of

as an input of

Inferred To

5-HT1B [plasma membrane] (Drosophila melanogaster)

HTR1A [plasma membrane] (Bos taurus)

HTR1A [plasma membrane] (Canis familiaris)

HTR1A [plasma membrane] (Gallus gallus)

HTR1A [plasma membrane] (Mus musculus)

HTR1A [plasma membrane] (Rattus norvegicus)

5-HT1A [plasma membrane] (Drosophila melanogaster)

htr1ab [plasma membrane] (Danio rerio)

Homologues of HTR1A [plasma membrane] (Drosophila melanogaster)

ser-4 [plasma membrane] (Caenorhabditis elegans)

LOC100489755 [plasma membrane] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

OpenTargets

ENSG00000178394

ENSEMBL

ENSP00000316244, ENST00000323865, ENSG00000178394

ZINC - FDA approved

5HT1A_HUMAN

ZINC - Substances

5HT1A_HUMAN

ZINC - Biogenic

5HT1A_HUMAN

ZINC target

P08908

PRO

P08908

GlyGen

P08908

PDB

8FYX, 8PKM, 7E2Z, 7E2X, 8FYT, 8W8B, 7E2Y, 8FYL, 8JT6, 8PJK, 8JSP, 8FY8, 8FYE

ZINC - Investigational

5HT1A_HUMAN

ZINC - Metabolites

5HT1A_HUMAN

HPA

ENSG00000178394-HTR1A

GeneCards

HTR1A

Pharos - Targets

P08908

ZINC - Predictions - Purchasable

5HT1A_HUMAN

Orphanet

HTR1A

HMDB Protein

HMDBP02566

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.62	9
UniProt:P47211 GALR1	1	GALR1 [plasma membrane] (R-HSA-388967)	0.585	4
UniProt:O43194 GPR39	1	GPR39 [plasma membrane] (R-HSA-443953)	0.571	4
UniProt:P08908 HTR1A	1	HTR1A [plasma membrane] (R-HSA-390971)	0.509	4