Reactome | HTR4 [plasma membrane]

HTR4 [plasma membrane]

Stable Identifier

R-HSA-391008

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5-HT4 receptor, RecName: Full=5-hydroxytryptamine receptor 4; Short=5-HT-4; Short=5-HT4; AltName: Full=Serotonin receptor 4;
GN Name=HTR4;
OS Homo sapiens, 5HT4R_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)
        
        HTR4,6,7:5HT [plasma membrane] (Homo sapiens)
        
        HTR4,6,7 [plasma membrane] (Homo sapiens)
        
        HTR4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13639 HTR4

Gene Names

HTR4

Chain

chain:1-388

Reference Genes

BioGPS Gene:3360 HTR4

COSMIC (genes):HTR4 HTR4

CTD Gene:3360 HTR4

dbSNP Gene:3360 HTR4

ENSEMBL:ENSG00000164270 HTR4

ENSEMBL_homo_sapiens_GENE:ENSG00000164270.19 HTR4

HGNC:5299 HTR4

KEGG Gene (Homo sapiens):3360 HTR4

Monarch:3360 HTR4

NCBI Gene:3360 HTR4

OMIM:602164 HTR4

UCSC:Q13639 HTR4

Reference Transcript

Other Identifiers

11735356_a_at

11742130_a_at

17001374

207577_PM_at

207577_at

207578_PM_s_at

207578_s_at

216939_PM_s_at

216939_s_at

2880553

2880554

2880558

2880564

2880565

2880566

2880567

2880568

2880569

2880578

2880579

2880581

2880586

2880587

2880602

2880603

2880605

3360

34466_at

34467_g_at

34468_at

8114977

A_23_P133637

A_24_P234768

GE563797

GO:0004930

GO:0004993

GO:0005515

GO:0005737

GO:0005768

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007268

GO:0016020

GO:0022600

GO:0023052

GO:0030277

GO:0030425

GO:0030594

GO:0031410

GO:0032098

GO:0043226

GO:0045202

GO:0060089

GO:0070254

GO:0098664

GO:0099589

GO:0120056

HMNXSV003044670

HMNXSV003052077

Hs.113262.0.S2_3p_at

Hs.113262.1.S1_3p_a_at

ILMN_1676350

ILMN_1786080

ILMN_1808258

ILMN_2410905

PH_hs_0006236

g11321562_3p_a_at

Participates

as a member of

HTR4,6,7 [plasma membrane] (Homo sapiens)

Inferred To

Dop1R1 [plasma membrane] (Drosophila melanogaster)

dop-1 [plasma membrane] (Caenorhabditis elegans)

HTR4 [plasma membrane] (Bos taurus)

HTR4 [plasma membrane] (Canis familiaris)

HTR4 [plasma membrane] (Gallus gallus)

HTR4 [plasma membrane] (Sus scrofa)

Htr4 [plasma membrane] (Mus musculus)

Htr4 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_955525.1, NP_000861.1, NP_001273339.1, NP_001035259.1, NP_001035263.1, NP_001035262.2

ZINC - World Drugs

5HT4R_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000164270

ZINC - Substances

5HT4R_HUMAN

ZINC target

Q13639

ZINC - Biogenic

5HT4R_HUMAN

PRO

Q13639

PDB

5EM9, 7XTA, 7XT9, 7XT8

ZINC - Investigational

5HT4R_HUMAN

ZINC - Metabolites

5HT4R_HUMAN

HPA

ENSG00000164270-HTR4

GeneCards

Q13639

Ensembl

ENSP00000367120, ENST00000521530, ENSP00000435904, ENSP00000428320, ENSP00000430979, ENSP00000427913, ENST00000360693, ENSP00000353915, ENSG00000164270, ENST00000521735, ENST00000520514, ENST00000377888, ENST00000522588, ENSP00000430874, ENST00000517929

Pharos - Targets

Q13639

ZINC - Predictions - Purchasable

5HT4R_HUMAN

HMDB Protein

HMDBP02219

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15354 GPR37	1	GPR37 [plasma membrane] (R-HSA-5333623)	0.581	5