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FBXL3 [cytosol]
Stable Identifier
R-HSA-391289
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Fbl3A
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
FBXL3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKT7 FBXL3
Gene Names
FBXL3, FBL3A, FBXL3A
Chain
chain:1-428
Reference Genes
BioGPS Gene:26224 FBXL3
COSMIC (genes):FBXL3 FBXL3
CTD Gene:26224 FBXL3
dbSNP Gene:26224 FBXL3
ENSEMBL:ENSG00000005812 FBXL3
ENSEMBL_homo_sapiens_GENE:ENSG00000005812.11 FBXL3
HGNC:13599 FBXL3
KEGG Gene (Homo sapiens):26224 FBXL3
Monarch:26224 FBXL3
NCBI Gene:26224 FBXL3
OMIM:605653 FBXL3
UCSC:Q9UKT7 FBXL3
Reference Transcript
RefSeq:NM_012158.2 FBXL3
RefSeq:XM_005266336.1 FBXL3
Other Identifiers
11717982_a_at
11758250_s_at
16779844
225132_PM_at
225132_at
26224
3518463
3518464
3518465
3518466
3518467
3518468
3518469
3518470
3518475
3518476
3518477
3518480
3518485
3518486
3518492
3518493
3518494
3518495
54900_at
62716_at
78141_at
7972062
83645_at
GE54837
GE858911
GO:0000151
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0016567
GO:0016604
GO:0016740
GO:0019005
GO:0030163
GO:0031146
GO:0031648
GO:0036211
GO:0042752
GO:0043153
GO:0043161
GO:0043226
GO:0048511
GO:0140096
HMNXSV003039762
Hs.7540.0.S1_3p_at
ILMN_2071405
TC13000742.hg
Participates
as a candidate of
unfolded CCT/TRiC substrate candidates [cytosol] (Homo sapiens)
as a member of
F-box protein [cytosol] (Homo sapiens)
Other forms of this molecule
FBXL3 [nucleoplasm]
Inferred To
Fbxl3 [cytosol]
(Mus musculus)
Fbxl3 [cytosol]
(Rattus norvegicus)
zgc:103721 [cytosol]
(Danio rerio)
FBXL3 [cytosol]
(Canis familiaris)
FBXL3 [cytosol]
(Gallus gallus)
FBXL3 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_005266393.1
,
NP_036290.1
OpenTargets
ENSG00000005812
HPA
ENSG00000005812-FBXL3
GeneCards
Q9UKT7
Ensembl
ENSP00000347834
,
ENSG00000005812
,
ENST00000355619
PRO
Q9UKT7
Pharos - Targets
Q9UKT7
PDB
4I6J
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9R194 Cry2
4
ub-p-Cry2 [nucleoplasm]
(R-MMU-517964)
p-Cry2 [nucleoplasm]
(R-MMU-508638)
p-Cry2 [cytosol]
(R-MMU-508666)
Cry2 [cytosol]
(R-MMU-508614)
0.78
13
UniProt:Q9WTX5 Skp1
2
Skp1 [nucleoplasm]
(R-MMU-9008726)
Skp1 [cytosol]
(R-MMU-174150)
0.623
4
UniProt:P97784 Cry1
4
Cry1 [cytosol]
(R-MMU-508637)
p-Cry1 [cytosol]
(R-MMU-508644)
p-Cry1 [nucleoplasm]
(R-MMU-508662)
ub-p-Cry1 [nucleoplasm]
(R-MMU-517961)
0.564
2
UniProt:Q86XR8-3 CEP57
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q9UJ68 MSRA
1
MSRA [cytosol]
(R-HSA-5676904)
0.556
3
UniProt:Q16526 CRY1
4
Ub-p-S-CRY1 [nucleoplasm]
(R-HSA-517931)
CRY1 [cytosol]
(R-HSA-400247)
p-S-CRY1 [nucleoplasm]
(R-HSA-400340)
p-S-CRY1 [cytosol]
(R-HSA-400270)
0.527
3
UniProt:P63209 SKP1
0.508
2
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