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TSHR [plasma membrane]
Stable Identifier
R-HSA-391371
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TSH receptor, RecName: Full=Thyrotropin receptor; AltName: Full=Thyroid-stimulating hormone receptor; Short=TSH-R; Flags: Precursor;
GN Name=TSHR; Synonyms=LGR3;
OS Homo sapiens, TSHR_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P21579%20SYT1
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)
TSHR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16473 TSHR
Gene Names
TSHR, LGR3
Chain
signal peptide:1-20, chain:21-764
Reference Genes
BioGPS Gene:7253 TSHR
COSMIC (genes):TSHR TSHR
CTD Gene:7253 TSHR
dbSNP Gene:7253 TSHR
ENSEMBL:ENSG00000165409 TSHR
ENSEMBL_homo_sapiens_GENE:ENSG00000165409.18 TSHR
HGNC:12373 TSHR
KEGG Gene (Homo sapiens):7253 TSHR
Monarch:7253 TSHR
NCBI Gene:7253 TSHR
UCSC:P16473 TSHR
Reference Transcript
RefSeq:NM_000369.2 TSHR
RefSeq:XM_005268039.1 TSHR
RefSeq:NM_001142626.2 TSHR
RefSeq:NM_001018036.2 TSHR
RefSeq:XM_006720245.1 TSHR
Other Identifiers
11730683_a_at
16787068
215442_PM_s_at
215442_s_at
215443_PM_at
215443_at
34514_at
34515_g_at
3546216
3546217
3546218
3546257
3546258
3546263
3546264
3546265
3546266
3546268
3546269
3546270
3546271
3546272
3546273
7253
7976037
A_14_P130131
GO:0004930
GO:0004996
GO:0005515
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007187
GO:0007189
GO:0007267
GO:0008284
GO:0008528
GO:0009755
GO:0009986
GO:0016020
GO:0016323
GO:0016500
GO:0023052
GO:0038023
GO:0038194
GO:0043235
GO:0044877
GO:0060089
GO:0120162
GO:1904588
GO:1905229
Hs.123078.1.S1_3p_at
ILMN_1660639
ILMN_2314121
Participates
as an input of
Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
as a component of
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
Inferred To
fshr-1 [plasma membrane]
(Caenorhabditis elegans)
Tshr [plasma membrane]
(Mus musculus)
Tshr [plasma membrane]
(Rattus norvegicus)
Lgr1 [plasma membrane]
(Drosophila melanogaster)
TSHR [plasma membrane]
(Bos taurus)
TSHR [plasma membrane]
(Canis familiaris)
TSHR [plasma membrane]
(Danio rerio)
TSHR [plasma membrane]
(Gallus gallus)
TSHR [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000360.2
,
XP_006720308.1
,
NP_001136098.1
,
XP_005268096.1
,
NP_001018046.1
Guide to Pharmacology - Targets
255
OpenTargets
ENSG00000165409
ZINC - Substances
TSHR_HUMAN
ZINC target
P16473
PRO
P16473
PDB
7XW5
,
3G04
,
7T9M
,
7XW7
,
2XWT
,
7XW6
ZINC - Investigational
TSHR_HUMAN
GeneCards
P16473
HPA
ENSG00000165409-TSHR
Ensembl
ENST00000342443
,
ENSP00000450549
,
ENSG00000165409
,
ENSP00000340113
,
ENST00000554435
Pharos - Targets
P16473
Orphanet
15670
ZINC - Predictions - Purchasable
TSHR_HUMAN
HMDB Protein
HMDBP02134
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.581
3
UniProt:P30542 ADORA1
1
ADORA1 [plasma membrane]
(R-HSA-418941)
0.508
2
UniProt:P21579 SYT1
7
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
0.508
2
UniProt:Q9NPA3 MID1IP1
1
MID1IP1 [cytosol]
(R-HSA-8867328)
0.508
2
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