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About
What is Reactome ?
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Team
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
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VHL [cytosol]
Stable Identifier
R-HSA-391423
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
VHL [cytosol] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-1 genome (Homo sapiens)
nsp16 binds VHL (Homo sapiens)
VHL [cytosol] (Homo sapiens)
nsp16:VHL [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
SARS-CoV-2 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-2 genome (Homo sapiens)
nsp16 binds VHL (Homo sapiens)
VHL [cytosol] (Homo sapiens)
nsp16:VHL [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
RHOBTB3 ATPase cycle (Homo sapiens)
RHOBTB3 binds interacting proteins at trans-Golgi network (Homo sapiens)
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Homo sapiens)
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
VHL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40337 VHL
Gene Names
VHL
Chain
chain:1-213
Reference Genes
BioGPS Gene:7428 VHL
COSMIC (genes):VHL VHL
CTD Gene:7428 VHL
dbSNP Gene:7428 VHL
ENSEMBL:ENSG00000134086 VHL
ENSEMBL:ENSG00000134086.9 VHL
HGNC:12687 VHL
KEGG Gene (Homo sapiens):7428 VHL
Monarch:7428 VHL
NCBI Gene:7428 VHL
OMIM:608537 VHL
UCSC:P40337 VHL
Reference Transcript
RefSeq:NM_198156.2 VHL
RefSeq:NM_000551.3 VHL
Other Identifiers
11748633_a_at
11752180_x_at
1559227_PM_s_at
1559227_s_at
1668_s_at
16937571
203844_PM_at
203844_at
2610338
2610339
2610340
2610342
2610344
2610345
2610346
2610347
2610348
2610349
2610350
2610351
2610352
2610353
2610354
40871_at
7428
8077781
A_23_P132606
A_24_P134942
A_33_P3419938
GE54104
GO:0000122
GO:0000902
GO:0001525
GO:0001666
GO:0003309
GO:0003310
GO:0003711
GO:0003714
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005783
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006508
GO:0006582
GO:0006914
GO:0008285
GO:0009968
GO:0010468
GO:0010498
GO:0010507
GO:0010629
GO:0012501
GO:0014069
GO:0015031
GO:0016020
GO:0016567
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030163
GO:0030182
GO:0030198
GO:0030891
GO:0031462
GO:0032880
GO:0034244
GO:0034330
GO:0036211
GO:0042069
GO:0043066
GO:0043226
GO:0043232
GO:0043534
GO:0044877
GO:0045446
GO:0045471
GO:0045597
GO:0045602
GO:0045893
GO:0046426
GO:0048069
GO:0048593
GO:0048856
GO:0048870
GO:0048877
GO:0050679
GO:0050821
GO:0060090
GO:0061072
GO:0061073
GO:0061428
GO:0061912
GO:0070243
GO:0070244
GO:0071456
GO:0097411
GO:0098978
GO:0099175
GO:0140096
GO:0140110
GO:0140252
GO:0140297
GO:1900037
GO:1902072
GO:1990000
GO:1990756
GO:2001233
HMNXSV003025175
Hs2.421597.1.A1_3p_s_at
ILMN_1738579
ILMN_1801984
ILMN_2376625
L15409_at
PH_hs_0033268
TC03000055.hg
TC03002213.hg
g4507890_3p_at
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Homo sapiens)
CUL2-box protein [cytosol] (Homo sapiens)
as an input of
nsp16 binds VHL (Homo sapiens)
nsp16 binds VHL (Homo sapiens)
as a component of
nsp16:VHL [cytosol] (Homo sapiens)
nsp16:VHL [cytosol] (Homo sapiens)
VBC complex [cytosol] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K159,171,196-VHL [nucleoplasm]
VHL [nucleoplasm]
Inferred To
Vhl [cytosol]
(Drosophila melanogaster)
Vhl [cytosol]
(Mus musculus)
Vhl [cytosol]
(Rattus norvegicus)
vhl-1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of VHL [cytosol]
(Xenopus tropicalis)
VHL [cytosol]
(Bos taurus)
VHL [cytosol]
(Canis familiaris)
VHL [cytosol]
(Danio rerio)
VHL [cytosol]
(Gallus gallus)
VHL [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_000542.1
,
NP_937799.1
Guide to Pharmacology - Targets
3204
OpenTargets
ENSG00000134086
ZINC - Substances
VHL_HUMAN
ZINC target
P40337
PRO
P40337
PDB
4W9I
,
6FMK
,
6HR2
,
8BDI
,
7Q2J
,
4AWJ
,
8BDT
,
6FMI
,
6BVB
,
3ZTD
,
1LQB
,
4W9C
,
6GFY
,
8BB2
,
8BDJ
,
4W9D
,
5NVW
,
6HAX
,
8BDL
,
6GMN
,
5NVX
,
5NW0
,
8BDX
,
4W9E
,
6I7Q
,
7Z76
,
8BEB
,
5NVZ
,
5N4W
,
7PI4
,
6GMQ
,
6ZHC
,
4BKS
,
3ZRC
,
4B9K
,
4W9G
,
6GMR
,
6I7R
,
4BKT
,
8BDN
,
6SIS
,
6R7F
,
5LLI
,
3ZTC
,
3ZRF
,
7S4E
,
4W9J
,
6FMJ
,
4WQO
,
6GMX
,
4W9K
,
7JTP
,
6GFZ
,
8BDS
,
7JTO
,
4W9L
,
7Z6L
,
6R6H
,
5NVV
,
7KHH
,
1LM8
,
4B95
,
6HAY
,
5NVY
,
8BB4
,
8BDM
,
5T35
,
4W9F
,
1VCB
,
5NW1
,
7ZNT
,
8BB3
,
5NW2
,
7CJB
,
8BDO
,
4W9H
,
3ZUN
,
7Z77
,
6GFX
,
8BB5
,
4AJY
,
8C13
GeneCards
P40337
HPA
ENSG00000134086-VHL
Ensembl
ENST00000345392
,
ENST00000256474
,
ENSG00000134086
,
ENSP00000344757
,
ENSP00000256474
Pharos - Targets
P40337
Orphanet
15708
ZINC - Predictions - Purchasable
VHL_HUMAN
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.957
20
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.928
11
UniProt:Q13617 CUL2
3
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
CUL2 [nucleoplasm]
(R-HSA-1234126)
CUL2 [cytosol]
(R-HSA-416982)
0.886
17
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.784
7
UniProt:Q99750 MDFI
0.666
4
UniProt:Q99814 EPAS1
5
HN-EPAS1 [cytosol]
(R-HSA-1234112)
2xHP-EPAS1 [cytosol]
(R-HSA-1234149)
2xHP-EPAS1 [nucleoplasm]
(R-HSA-1234151)
EPAS1 [nucleoplasm]
(R-HSA-452560)
EPAS1 [cytosol]
(R-HSA-1234119)
0.659
3
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.623
4
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.611
9
UniProt:P0C6X7-PRO_0000037322 REP
0.602
7
UniProt:P21980 TGM2
0.602
10
UniProt:Q99873 PRMT1
2
PRMT1 [cytosol]
(R-HSA-9632173)
PRMT1 [nucleoplasm]
(R-HSA-3215140)
0.508
2
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.499
2
UniProt:Q61221
7
Hif1a [cytosol]
(R-MMU-1234110)
Hif1a [nucleoplasm]
(R-MMU-1234105)
Hif1a [cytosol]
(R-MMU-1234131)
phospho-Hif1a [cytosol]
(R-MMU-9634700)
phospho-Hif1a [cytosol]
(R-MMU-8857584)
Hif1a [cytosol]
(R-MMU-1234102)
Hif1a [nucleoplasm]
(R-MMU-1234135)
0.499
3
UniProt:Q05513 PRKCZ
5
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cell junction]
(R-HSA-2134483)
PRKCZ [cytosol]
(R-HSA-58218)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
0.463
3
UniProt:P08151 GLI1
9
ub-pS-GLI1 [ciliary base]
(R-HSA-5610514)
pS-GLI1 [ciliary base]
(R-HSA-5610497)
ub-GLI1 [cytosol]
(R-HSA-5635833)
GLI1 [cytosol]
(R-HSA-445457)
p-GLI1 [ciliary tip]
(R-HSA-5635040)
2p-GLI1 [nucleoplasm]
(R-HSA-5635057)
p-GLI1 [nucleoplasm]
(R-HSA-5635042)
GLI1 [ciliary tip]
(R-HSA-5610360)
GLI1 [ciliary base]
(R-HSA-5610357)
0.463
2
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