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About
What is Reactome ?
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Digital Preservation
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SPTB [cytosol]
Stable Identifier
R-HSA-391565
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Spectrin beta chain, erythrocyte, SPTB1_HUMAN, Beta-I spectrin
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Phosphorylation of FAK by Src kinase (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11277 SPTB
Gene Names
SPTB, SPTB1
Chain
initiator methionine:, chain:2-2137
Reference Genes
BioGPS Gene:6710 SPTB
COSMIC (genes):SPTB SPTB
CTD Gene:6710 SPTB
dbSNP Gene:6710 SPTB
ENSEMBL:ENSG00000070182 SPTB
ENSEMBL_homo_sapiens_GENE:ENSG00000070182.21 SPTB
HGNC:11274 SPTB
KEGG Gene (Homo sapiens):6710 SPTB
Monarch:6710 SPTB
NCBI Gene:6710 SPTB
OMIM:182870 SPTB
UCSC:P11277 SPTB
Reference Transcript
RefSeq:NM_000347.5 SPTB
RefSeq:XM_005268023.4 SPTB
RefSeq:NM_001024858.2 SPTB
RefSeq:XM_017021614.1 SPTB
RefSeq:XM_017021612.1 SPTB
Other Identifiers
11726398_a_at
11726399_at
11729970_a_at
11729971_at
16793830
208416_PM_s_at
208416_s_at
214145_PM_s_at
214145_s_at
3568437
3568438
3568439
3568484
3568486
3568487
3568488
3568489
3568490
3568491
3568493
3568495
3568497
3568499
3568501
3568505
3568507
3568533
3568535
3568536
3568537
3568538
3568539
3568540
3568541
3568542
3568543
3568544
3568545
3568546
3568547
3568548
3568549
3568550
3568551
3568552
3568553
3568554
3568555
3568556
3568557
3568558
3568559
3568560
3568561
3568562
3568563
3568564
3568565
3568566
3568567
3568568
3568569
36036_at
36037_g_at
36038_r_at
40958_at
6710
7979615
A_23_P65506
A_24_P272088
A_32_P134968
A_32_P134974
GE57531
GE61668
GO:0003779
GO:0005198
GO:0005200
GO:0005515
GO:0005543
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005938
GO:0007010
GO:0008091
GO:0008092
GO:0008289
GO:0009898
GO:0009986
GO:0014731
GO:0015629
GO:0016020
GO:0030036
GO:0030054
GO:0030506
GO:0030864
GO:0032991
GO:0034330
GO:0042995
GO:0043226
GO:0051015
GO:0051693
GO:0065003
GO:0098794
GO:0098885
GO:0098978
HMNXSV003026830
Hs.198037.1.S1_3p_at
Hs.198037.1.S1_3p_x_at
ILMN_1663106
ILMN_1667494
ILMN_1782845
J05500_at
PH_hs_0020755
TC14001220.hg
g10334855_3p_a_at
Participates
as a member of
Spectrin beta chain [cytosol] (Homo sapiens)
Inferred To
unc-70 [cytosol]
(Caenorhabditis elegans)
SPTB [cytosol]
(Bos taurus)
SPTB [cytosol]
(Canis familiaris)
SPTB [cytosol]
(Dictyostelium discoideum)
SPTB [cytosol]
(Sus scrofa)
beta-Spec [cytosol]
(Drosophila melanogaster)
Homologues of SPTB [cytosol]
(Dictyostelium discoideum)
Sptb [cytosol]
(Mus musculus)
Sptb [cytosol]
(Rattus norvegicus)
sptb [cytosol]
(Xenopus tropicalis)
ain1 [cytosol]
(Schizosaccharomyces pombe)
abpD [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001020029.1
,
NP_000338.3
,
XP_016877101.1
,
XP_016877103.1
,
XP_005268080.1
OpenTargets
ENSG00000070182
GeneCards
P11277
HPA
ENSG00000070182-SPTB
Ensembl
ENST00000389720
,
ENSP00000374372
,
ENST00000644917
,
ENSP00000495909
,
ENST00000389722
,
ENSP00000374370
,
ENSG00000070182
PRO
P11277
Pharos - Targets
P11277
Orphanet
15553
PDB
3KBU
,
3KBT
,
3EDU
,
1S35
,
3F57
,
3LBX
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
6
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.488
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.488
2
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![SPTB [cytosol] icon](/icon/R-ICO-013708.svg){kind=icon}
