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PTGER3 [plasma membrane]
Stable Identifier
R-HSA-391828
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EP3 receptor, RecName: Full=Prostaglandin E2 receptor EP3 subtype; Short=PGE receptor, EP3 subtype; Short=PGE2-R; AltName: Full=Prostanoid EP3 receptor;
GN Name=PTGER3;
OS Homo sapiens, PE2R3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O00459 PIK3R2
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
EP3 receptor can bind PGE2 (Homo sapiens)
PTGER3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43115 PTGER3
Gene Names
PTGER3
Chain
chain:1-390
Reference Genes
BioGPS Gene:5733 PTGER3
COSMIC (genes):PTGER3 PTGER3
CTD Gene:5733 PTGER3
dbSNP Gene:5733 PTGER3
ENSEMBL:ENSG00000050628 PTGER3
ENSEMBL_homo_sapiens_GENE:ENSG00000050628.21 PTGER3
HGNC:9595 PTGER3
KEGG Gene (Homo sapiens):5733 PTGER3
Monarch:5733 PTGER3
NCBI Gene:5733 PTGER3
OMIM:176806 PTGER3
UCSC:P43115 PTGER3
Reference Transcript
RefSeq:NM_001126044.1 PTGER3
RefSeq:NM_198715.2 PTGER3
RefSeq:NM_198714.1 PTGER3
RefSeq:NM_198717.1 PTGER3
RefSeq:NM_198719.1 PTGER3
RefSeq:NM_198716.1 PTGER3
RefSeq:NM_198718.1 PTGER3
Other Identifiers
11730484_at
11735111_a_at
11735112_at
11735113_at
11741984_a_at
11742257_a_at
11752844_x_at
16688469
208169_PM_s_at
208169_s_at
210374_PM_x_at
210374_x_at
210375_PM_at
210375_at
210831_PM_s_at
210831_s_at
210832_PM_x_at
210832_x_at
210833_PM_at
210833_at
210834_PM_s_at
210834_s_at
211909_3p_x_at
211909_PM_x_at
211909_x_at
213933_PM_at
213933_at
2417946
2417947
2417955
2417956
2417960
2417970
2417971
2417972
2417973
2417977
2417978
2417979
2417980
2417981
2417982
2417983
2417984
2417985
2417995
2417996
2417997
2417998
2417999
32686_at
32687_s_at
32688_at
32689_s_at
32690_s_at
32692_at
39616_at
5733
66738_at
7916944
79717_at
A_23_P103328
A_24_P945365
A_33_P3265739
A_33_P3265744
A_33_P3265749
D86096_cds1_s_at
D86096_cds3_at
D86096_cds6_at
GE80971
GO:0003012
GO:0004930
GO:0004955
GO:0004957
GO:0005634
GO:0005635
GO:0005886
GO:0006954
GO:0007165
GO:0007186
GO:0007189
GO:0007200
GO:0007204
GO:0008219
GO:0014827
GO:0016020
GO:0022600
GO:0023052
GO:0031622
GO:0043226
GO:0060089
GO:0060455
HMNXSV003020687
Hs.170917.6.S2_3p_at
Hs.170917.7.S2_3p_at
Hs.27860.0.S1_3p_at
ILMN_1677384
ILMN_1743361
ILMN_1759542
ILMN_2290444
ILMN_2290453
ILMN_2353110
PH_hs_0022071
S68874_s_at
TC01005553.hg
TC01005554.hg
X83857_s_at
g440311_3p_a_at
g484163_3p_x_at
Participates
as an input of
EP3 receptor can bind PGE2 (Homo sapiens)
as a component of
PTGER3:PGE2 [plasma membrane] (Homo sapiens)
Inferred To
PTGER3 [plasma membrane]
(Bos taurus)
PTGER3 [plasma membrane]
(Canis familiaris)
PTGER3 [plasma membrane]
(Sus scrofa)
EP3 [plasma membrane]
(Gallus gallus)
Ptger3 [plasma membrane]
(Mus musculus)
Ptger3 [plasma membrane]
(Rattus norvegicus)
BcDNA:GH27361 [plasma membrane]
(Drosophila melanogaster)
ptger3 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_942009.1
,
NP_942008.1
,
NP_942007.1
,
NP_942010.1
,
NP_942011.1
,
NP_001119516.1
,
NP_942012.1
ZINC - World Drugs
PE2R3_HUMAN
Guide to Pharmacology - Targets
342
OpenTargets
ENSG00000050628
ZINC - FDA approved
PE2R3_HUMAN
ZINC - Substances
PE2R3_HUMAN
ZINC target
P43115
ZINC - Biogenic
PE2R3_HUMAN
PRO
P43115
PDB
8GDC
,
7WU9
,
6AK3
,
6M9T
ZINC - Investigational
PE2R3_HUMAN
ZINC - Metabolites
PE2R3_HUMAN
HPA
ENSG00000050628-PTGER3
GeneCards
P43115
Ensembl
ENSP00000359962
,
ENST00000479353
,
ENST00000306666
,
ENSG00000050628
,
ENST00000356595
,
ENST00000370931
,
ENSP00000349003
,
ENSP00000302313
,
ENST00000370924
,
ENSP00000359969
,
ENSP00000418073
,
ENST00000628037
,
ENSP00000421583
,
ENST00000460330
,
ENSP00000486617
Pharos - Targets
P43115
ZINC - Predictions - Purchasable
PE2R3_HUMAN
HMDB Protein
HMDBP07938
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P36894 BMPR1A
2
BMPR1A [plasma membrane]
(R-HSA-201480)
p-4S-BMPR1A [plasma membrane]
(R-HSA-201448)
0.527
2
UniProt:P42338 PIK3CB
1
PIK3CB [cytosol]
(R-HSA-74788)
0.527
2
UniProt:Q9NY26 SLC39A1
1
SLC39A1 [plasma membrane]
(R-HSA-442329)
0.527
2
UniProt:Q86VM9 ZCH18
0.527
2
UniProt:P19634 SLC9A1
1
SLC9A1 [plasma membrane]
(R-HSA-426006)
0.527
2
UniProt:Q96S97 MYADM
0.527
2
UniProt:P49770 EIF2B2
1
EIF2B2 [cytosol]
(R-HSA-72519)
0.527
2
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.527
2
UniProt:Q86YS7 C2CD5
2
p-S197-C2CD5 [plasma membrane]
(R-HSA-5260194)
C2CD5 [plasma membrane]
(R-HSA-5216175)
0.527
2
UniProt:Q9BSJ2 TUBGCP2
1
TUBGCP2 [cytosol]
(R-HSA-379275)
0.527
2
UniProt:P27037 ACVR2A
1
ACVR2A [plasma membrane]
(R-HSA-201659)
0.527
2
UniProt:Q8N8L6 ARL10
0.527
2
UniProt:Q6ZTN6 AN13D
0.527
2
UniProt:Q5SWA1 PR15B
0.527
2
UniProt:P55082 MFAP3
1
MFAP3 [extracellular region]
(R-HSA-2161382)
0.527
2
UniProt:Q7Z4Q2 HEAT3
0.527
2
UniProt:O95373 IPO7
0.527
2
UniProt:Q6PL24 TMED8
0.527
2
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.527
2
UniProt:Q6P5Z2 PKN3
2
p-T718-PKN3 [cytosol]
(R-HSA-5623654)
PKN3 [cytosol]
(R-HSA-5623611)
0.527
2
UniProt:O15397 IPO8
2
IPO8 [cytosol]
(R-HSA-5578740)
IPO8 [nucleoplasm]
(R-HSA-5578747)
0.527
2
UniProt:Q86U38 NOP9
0.527
2
UniProt:Q9NR50 EIF2B3
1
EIF2B3 [cytosol]
(R-HSA-72525)
0.527
2
UniProt:Q96CN4 EVI5L
0.527
2
UniProt:Q96P70 IPO9
0.527
2
UniProt:Q6NUM6 TYW1B
0.527
2
UniProt:Q13705 ACVR2B
1
ACVR2B [plasma membrane]
(R-HSA-201656)
0.527
2
UniProt:Q96ER3 SAAL1
0.527
2
UniProt:Q9C0E2 XPO4
0.527
2
UniProt:Q14232 EIF2B1
1
EIF2B1 [cytosol]
(R-HSA-72517)
0.527
2
UniProt:Q13144 EIF2B5
1
EIF2B5 [cytosol]
(R-HSA-72523)
0.527
2
UniProt:Q9HCG8 CWC22
1
CWC22 [nucleoplasm]
(R-HSA-8865956)
0.527
2
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