Reactome | PTGER3 [plasma membrane]

PTGER3 [plasma membrane]

Stable Identifier

R-HSA-391828

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

EP3 receptor, RecName: Full=Prostaglandin E2 receptor EP3 subtype; Short=PGE receptor, EP3 subtype; Short=PGE2-R; AltName: Full=Prostanoid EP3 receptor;
GN Name=PTGER3;
OS Homo sapiens, PE2R3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96P70 IPO9

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        EP3 receptor can bind PGE2 (Homo sapiens)
        
        PTGER3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43115 PTGER3

Gene Names

PTGER3

Chain

chain:1-390

Reference Genes

BioGPS Gene:5733 PTGER3

COSMIC (genes):PTGER3 PTGER3

CTD Gene:5733 PTGER3

dbSNP Gene:5733 PTGER3

ENSEMBL:ENSG00000050628 PTGER3

HGNC:9595 PTGER3

KEGG:hsa:5733 PTGER3

Monarch:5733 PTGER3

NCBI Gene:5733 PTGER3

OMIM:176806 PTGER3

UCSC:P43115 PTGER3

Reference Transcript

Participates

as an input of

EP3 receptor can bind PGE2 (Homo sapiens)

as a component of

PTGER3:PGE2 [plasma membrane] (Homo sapiens)

Inferred To

PTGER3 [plasma membrane] (Bos taurus)

PTGER3 [plasma membrane] (Canis familiaris)

PTGER3 [plasma membrane] (Sus scrofa)

EP3 [plasma membrane] (Gallus gallus)

Ptger3 [plasma membrane] (Mus musculus)

Ptger3 [plasma membrane] (Rattus norvegicus)

BcDNA:GH27361 [plasma membrane] (Drosophila melanogaster)

ptger3 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_942009.1, NP_942008.1, NP_942007.1, NP_001119516.1, NP_942011.1, NP_942010.1, NP_942012.1

Guide to Pharmacology - Targets

342

OpenTargets

ENSG00000050628

ENSEMBL

ENST00000356595, ENSG00000050628, ENSP00000359962, ENST00000306666, ENSP00000349003, ENSP00000359969, ENSP00000418073, ENSP00000421583, ENSP00000486617, ENST00000479353, ENST00000370931, ENST00000460330, ENST00000628037, ENSP00000302313, ENST00000370924

ZINC - FDA approved

PE2R3_HUMAN

ZINC - Substances

PE2R3_HUMAN

ZINC - Biogenic

PE2R3_HUMAN

ZINC target

P43115

PRO

P43115

GlyGen

P43115

PDB

6AK3, 6M9T, 8GDC, 7WU9

ZINC - Investigational

PE2R3_HUMAN

ZINC - Metabolites

PE2R3_HUMAN

GeneCards

PTGER3

HPA

ENSG00000050628-PTGER3

Pharos - Targets

P43115

ZINC - Predictions - Purchasable

PE2R3_HUMAN

HMDB Protein

HMDBP07938

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.527	2
UniProt:Q9HCG8 CWC22	1	CWC22 [nucleoplasm] (R-HSA-8865956)	0.527	2
UniProt:P27037 ACVR2A	1	ACVR2A [plasma membrane] (R-HSA-201659)	0.527	2
UniProt:Q14232 EIF2B1	1	EIF2B1 [cytosol] (R-HSA-72517)	0.527	2
UniProt:Q13144 EIF2B5	1	EIF2B5 [cytosol] (R-HSA-72523)	0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:Q96ER3 SAAL1			0.527	2
UniProt:Q13705 ACVR2B	1	ACVR2B [plasma membrane] (R-HSA-201656)	0.527	2
UniProt:Q6NUM6 TYW1B			0.527	2
UniProt:Q96CN4 EVI5L			0.527	2
UniProt:Q96P70 IPO9			0.527	2
UniProt:Q9NR50 EIF2B3	1	EIF2B3 [cytosol] (R-HSA-72525)	0.527	2
UniProt:Q86U38 NOP9			0.527	2
UniProt:Q6P5Z2 PKN3	2	p-T718-PKN3 [cytosol] (R-HSA-5623654) PKN3 [cytosol] (R-HSA-5623611)	0.527	2
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.527	2
UniProt:Q6PL24 TMED8			0.527	2
UniProt:O95373 IPO7			0.527	2
UniProt:Q7Z4Q2 HEAT3			0.527	2
UniProt:P55082 MFAP3	1	MFAP3 [extracellular region] (R-HSA-2161382)	0.527	2
UniProt:Q5SWA1 PR15B			0.527	2
UniProt:Q6ZTN6 AN13D			0.527	2
UniProt:Q8N8L6 ARL10			0.527	2
UniProt:Q9BSJ2 TUBGCP2	1	TUBGCP2 [cytosol] (R-HSA-379275)	0.527	2
UniProt:Q86YS7 C2CD5	2	C2CD5 [plasma membrane] (R-HSA-5216175) p-S197-C2CD5 [plasma membrane] (R-HSA-5260194)	0.527	2
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.527	2
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	2
UniProt:Q96S97 MYADM			0.527	2
UniProt:P19634 SLC9A1	1	SLC9A1 [plasma membrane] (R-HSA-426006)	0.527	2
UniProt:Q9NY26 SLC39A1	1	SLC39A1 [plasma membrane] (R-HSA-442329)	0.527	2
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.527	2
UniProt:P36894 BMPR1A	2	BMPR1A [plasma membrane] (R-HSA-201480) p-4S-BMPR1A [plasma membrane] (R-HSA-201448)	0.527	2

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