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PTGIR [plasma membrane]
Stable Identifier
R-HSA-391834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IP receptor, RecName: Full=Prostacyclin receptor; AltName: Full=Prostanoid IP receptor; AltName: Full=PGI receptor; AltName: Full=Prostaglandin I2 receptor;
GN Name=PTGIR; Synonyms=PRIPR;
OS Homo sapiens, PI2R_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Gs activation by prostacyclin receptor (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
PTGIR binds PTGIR agonists (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
PTGIR:PTGIR agonists [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43119 PTGIR
Gene Names
PTGIR, PRIPR
Chain
chain:1-383, propeptide:384-386
Reference Genes
BioGPS Gene:5739 PTGIR
COSMIC (genes):PTGIR PTGIR
CTD Gene:5739 PTGIR
dbSNP Gene:5739 PTGIR
ENSEMBL:ENSG00000160013 PTGIR
ENSEMBL_homo_sapiens_GENE:ENSG00000160013.9 PTGIR
HGNC:9602 PTGIR
KEGG Gene (Homo sapiens):5739 PTGIR
Monarch:5739 PTGIR
NCBI Gene:5739 PTGIR
OMIM:600022 PTGIR
UCSC:P43119 PTGIR
Reference Transcript
RefSeq:NM_000960.3 PTGIR
Other Identifiers
11726062_at
11758292_s_at
1555620_3p_a_at
1555620_PM_a_at
1555620_a_at
16873562
206187_PM_at
206187_at
3866095
3866096
3866101
3866104
5739
758_at
8037775
A_23_P340848
A_24_P322426
D38128_at
GE901484
GO:0004930
GO:0005085
GO:0005829
GO:0005886
GO:0006954
GO:0007165
GO:0007186
GO:0007187
GO:0007189
GO:0007204
GO:0007267
GO:0010642
GO:0016020
GO:0016501
GO:0023052
GO:0032496
GO:0048662
GO:0060089
GO:0098772
HMNXSV003009353
Hs2.393.2.S1_3p_s_at
ILMN_1747023
PH_hs_0026352
TC19001650.hg
g4506262_3p_at
Participates
as a component of
PTGIR:PTGIR agonists [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
as an input of
PTGIR binds PTGIR agonists (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
as an output of
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
Inferred To
Ptgir [plasma membrane]
(Mus musculus)
Ptgir [plasma membrane]
(Rattus norvegicus)
BcDNA:GH27361 [plasma membrane]
(Drosophila melanogaster)
PTGIR [plasma membrane]
(Bos taurus)
PTGIR [plasma membrane]
(Canis familiaris)
PTGIR [plasma membrane]
(Danio rerio)
PTGIR [plasma membrane]
(Sus scrofa)
ptgir [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000951.1
ZINC - World Drugs
PI2R_HUMAN
Guide to Pharmacology - Targets
345
OpenTargets
ENSG00000160013
ZINC - FDA approved
PI2R_HUMAN
ZINC - Substances
PI2R_HUMAN
ZINC target
P43119
ZINC - Biogenic
PI2R_HUMAN
PRO
P43119
ZINC - Investigational
PI2R_HUMAN
ZINC - Metabolites
PI2R_HUMAN
GeneCards
P43119
HPA
ENSG00000160013-PTGIR
Ensembl
ENSG00000160013
,
ENSP00000291294
,
ENST00000291294
Pharos - Targets
P43119
ZINC - Predictions - Purchasable
PI2R_HUMAN
HMDB Protein
HMDBP02751
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