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PTGIR [plasma membrane]
Stable Identifier
R-HSA-391834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IP receptor, RecName: Full=Prostacyclin receptor; AltName: Full=Prostanoid IP receptor; AltName: Full=PGI receptor; AltName: Full=Prostaglandin I2 receptor;
GN Name=PTGIR; Synonyms=PRIPR;
OS Homo sapiens, PI2R_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9UBU6 FA8A1
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Prostacyclin signalling through prostacyclin receptor (Homo sapiens)
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
PTGIR binds PTGIR agonists (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
PTGIR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43119 PTGIR
Gene Names
PTGIR, PRIPR
Chain
chain:1-383, propeptide:384-386
Reference Genes
BioGPS Gene:5739 PTGIR
COSMIC (genes):PTGIR PTGIR
CTD Gene:5739 PTGIR
dbSNP Gene:5739 PTGIR
ENSEMBL:ENSG00000160013 PTGIR
HGNC:9602 PTGIR
KEGG:hsa:5739 PTGIR
Monarch:5739 PTGIR
NCBI Gene:5739 PTGIR
OMIM:600022 PTGIR
UCSC:P43119 PTGIR
Reference Transcript
RefSeq:NM_000960.3 PTGIR
Other Identifiers
11726062_at
11758292_s_at
1555620_3p_a_at
1555620_PM_a_at
1555620_a_at
16873562
206187_PM_at
206187_at
3866095
3866096
3866097
3866098
3866099
3866100
3866101
3866102
3866103
3866104
5739
758_at
8037775
A_23_P340848
A_24_P322426
D38128_at
GE901484
GO:0004930
GO:0005085
GO:0005829
GO:0005886
GO:0006954
GO:0007186
GO:0007187
GO:0007189
GO:0007204
GO:0007267
GO:0010642
GO:0016020
GO:0016501
GO:0023052
GO:0032496
GO:0048662
GO:0060089
GO:0098772
HMNXSV003009353
Hs2.393.2.S1_3p_at
Hs2.393.2.S1_3p_s_at
ILMN_1747023
PH_hs_0026352
TC19001650.hg
g4506262_3p_at
Participates
as a component of
PTGIR:PTGIR agonists [plasma membrane] (Homo sapiens)
PTGIR:PGI2 [plasma membrane] (Homo sapiens)
as an input of
PTGIR binds PTGIR agonists (Homo sapiens)
IP receptor can bind prostacyclin (Homo sapiens)
as an output of
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
Inferred To
Ptgir [plasma membrane]
(Mus musculus)
Ptgir [plasma membrane]
(Rattus norvegicus)
BcDNA:GH27361 [plasma membrane]
(Drosophila melanogaster)
PTGIR [plasma membrane]
(Bos taurus)
PTGIR [plasma membrane]
(Canis familiaris)
PTGIR [plasma membrane]
(Sus scrofa)
ptgir [plasma membrane]
(Danio rerio)
ptgir [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000951.1
ZINC - World Drugs
PI2R_HUMAN
Guide to Pharmacology - Targets
345
OpenTargets
ENSG00000160013
ENSEMBL
ENSP00000291294
,
ENST00000291294
ZINC - FDA approved
PI2R_HUMAN
ZINC - Substances
PI2R_HUMAN
ZINC - Biogenic
PI2R_HUMAN
ZINC target
P43119
PRO
P43119
GlyGen
P43119
PDB
8X7A
,
8X79
ZINC - Investigational
PI2R_HUMAN
ZINC - Metabolites
PI2R_HUMAN
HPA
ENSG00000160013-PTGIR
Pharos - Targets
P43119
ZINC - Predictions - Purchasable
PI2R_HUMAN
HMDB Protein
HMDBP02751
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7L8W6 DPH6
1
DPH6 [cytosol]
(R-HSA-5358469)
0.527
2
UniProt:O95427 PIGN
1
PIGN [endoplasmic reticulum membrane]
(R-HSA-162724)
0.527
2
UniProt:Q16739 UGCG
1
UGCG [Golgi membrane]
(R-HSA-1631585)
0.527
2
UniProt:Q9H6D3 XKR8
0.527
2
UniProt:Q99808 SLC29A1
1
SLC29A1 [plasma membrane]
(R-HSA-54335)
0.527
2
UniProt:Q75V66 ANO5
1
ANO5 [plasma membrane]
(R-HSA-2684890)
0.527
2
UniProt:Q5T3F8 CSCL2
0.527
2
UniProt:Q14332 FZD2
2
FZD2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140723)
FZD2 [plasma membrane]
(R-HSA-443945)
0.527
2
UniProt:Q13563 PKD2
3
PKD2 [Golgi membrane]
(R-HSA-5623393)
PKD2 [Golgi-associated vesicle membrane]
(R-HSA-5623411)
PKD2 [ciliary membrane]
(R-HSA-5623409)
0.527
2
UniProt:Q9H819 DJC18
0.527
2
UniProt:P48029 SLC6A8
1
SLC6A8 [plasma membrane]
(R-HSA-200393)
0.527
2
UniProt:Q86Y56 DAAF5
0.527
2
UniProt:O94886 TMEM63A
3
TMEM63A [tertiary granule membrane]
(R-HSA-6800945)
TMEM63A [plasma membrane]
(R-HSA-6800445)
TMEM63A [specific granule membrane]
(R-HSA-6799721)
0.527
2
UniProt:Q9P2E7 PCD10
0.527
2
UniProt:Q92990 GLMN
1
GLMN [cytosol]
(R-HSA-8951779)
0.527
2
UniProt:P55082 MFAP3
1
MFAP3 [extracellular region]
(R-HSA-2161382)
0.527
2
UniProt:P36383 GJC1
2
GJC1 [plasma membrane]
(R-HSA-383285)
GJC1 [endoplasmic reticulum membrane]
(R-HSA-190716)
0.527
2
UniProt:Q8N697 SLC15A4
4
SLC15A4 [lysosomal membrane]
(R-HSA-428039)
SLC15A4 [endolysosome membrane]
(R-HSA-9860282)
SLC15A4 [plasma membrane]
(R-HSA-6800447)
SLC15A4 [specific granule membrane]
(R-HSA-6799715)
0.527
2
UniProt:Q6NSJ5 LRRC8E
1
LRRC8E [plasma membrane]
(R-HSA-8941539)
0.527
2
UniProt:Q9Y666 SLC12A7
1
SLC12A7 [plasma membrane]
(R-HSA-426164)
0.527
2
UniProt:P24468 NR2F2
1
NR2F2 [nucleoplasm]
(R-HSA-1183002)
0.527
2
UniProt:Q9BXP2 S12A9
0.527
2
UniProt:Q7Z7N9 TMEM179B
4
TMEM179B [azurophil granule membrane]
(R-HSA-6799362)
TMEM179B [secretory granule membrane]
(R-HSA-6801009)
TMEM179B [plasma membrane]
(R-HSA-6806263)
TMEM179B [ficolin-1-rich granule membrane]
(R-HSA-6800989)
0.527
2
UniProt:Q8NHS3 MFSD8
0.527
2
UniProt:Q9Y6M5 SLC30A1
1
SLC30A1 [plasma membrane]
(R-HSA-435361)
0.527
2
UniProt:P19634 SLC9A1
1
SLC9A1 [plasma membrane]
(R-HSA-426006)
0.527
2
UniProt:Q9UEW8 STK39
0.527
2
UniProt:Q9UBU6 FA8A1
0.527
2
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