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PTGER1 [plasma membrane]
Stable Identifier
R-HSA-391838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EP1 receptor, RecName: Full=Prostaglandin E2 receptor EP1 subtype; AltName: Full=Prostanoid EP1 receptor; AltName: Full=PGE receptor, EP1 subtype;
GN Name=PTGER1;
OS Homo sapiens, PE2R1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGER1:PGE2 [plasma membrane] (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGER1:PGE2 [plasma membrane] (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGER1:PGE2 [plasma membrane] (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGER1:PGE2 [plasma membrane] (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGER1:PGE2 [plasma membrane] (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
EP1 receptor can bind PGE2 (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
PTGER1:PGE2 [plasma membrane] (Homo sapiens)
PTGER1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34995 PTGER1
Gene Names
PTGER1
Chain
chain:1-402
Reference Genes
BioGPS Gene:5731 PTGER1
COSMIC (genes):PTGER1 PTGER1
CTD Gene:5731 PTGER1
dbSNP Gene:5731 PTGER1
ENSEMBL:ENSG00000160951 PTGER1
ENSEMBL_homo_sapiens_GENE:ENSG00000160951.4 PTGER1
HGNC:9593 PTGER1
KEGG Gene (Homo sapiens):5731 PTGER1
Monarch:5731 PTGER1
NCBI Gene:5731 PTGER1
OMIM:176802 PTGER1
UCSC:P34995 PTGER1
Reference Transcript
RefSeq:NM_000955.2 PTGER1
Other Identifiers
11733234_at
16869639
207650_PM_x_at
207650_x_at
214391_3p_x_at
214391_PM_x_at
214391_x_at
38209_at
3852738
3852739
3852741
3852742
5731
8034821
A_23_P4808
GE79421
GO:0004930
GO:0004955
GO:0004957
GO:0005886
GO:0006954
GO:0007165
GO:0007186
GO:0007189
GO:0007191
GO:0007204
GO:0016020
GO:0023052
GO:0031748
GO:0032496
GO:0060089
HMNXSV003056308
Hs.159360.2.A1_3p_a_at
Hs.159360.2.A1_3p_at
ILMN_1744929
TC19001237.hg
TC19002355.hg
g4506252_3p_at
Participates
as an input of
EP1 receptor can bind PGE2 (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
PTGER1:PGE2 [plasma membrane] (Homo sapiens)
Inferred To
Ptger1 [plasma membrane]
(Mus musculus)
Ptger1 [plasma membrane]
(Rattus norvegicus)
ptger1 [plasma membrane]
(Xenopus tropicalis)
ptger1a [plasma membrane]
(Danio rerio)
BcDNA:GH27361 [plasma membrane]
(Drosophila melanogaster)
PTGER1 [plasma membrane]
(Bos taurus)
PTGER1 [plasma membrane]
(Canis familiaris)
PTGER1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000946.2
ZINC - World Drugs
PE2R1_HUMAN
Guide to Pharmacology - Targets
340
OpenTargets
ENSG00000160951
ZINC - FDA approved
PE2R1_HUMAN
ZINC - Substances
PE2R1_HUMAN
ZINC - Biogenic
PE2R1_HUMAN
ZINC target
P34995
PRO
P34995
ZINC - Investigational
PE2R1_HUMAN
ZINC - Metabolites
PE2R1_HUMAN
GeneCards
P34995
HPA
ENSG00000160951-PTGER1
Ensembl
ENSG00000160951
,
ENST00000292513
,
ENSP00000292513
Pharos - Targets
P34995
ZINC - Predictions - Purchasable
PE2R1_HUMAN
HMDB Protein
HMDBP02385
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