Reactome | Eicosanoid ligand-binding receptors

Eicosanoid ligand-binding receptors

Stable Identifier

R-HSA-391903

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Eicosanoids, derived from polyunsaturated 20-carbon fatty acids, are paracrine and autocrine regulators of inflammation, smooth muscle contraction, and blood coagulation. The actions of eicosanoids are mediated by eicosanoid receptors, most of which are GPCRs. There are four types of eicosanoid GPCRs in humans; leukotriene, lipoxin (Brink C et al, 2003), prostanoid (Coleman RA et al, 1994) and oxoeicosanoid (Brink C et al, 2004) receptors.

Literature References

PubMed ID	Title	Journal	Year
15001665	International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor Evans, JF, Dahlén, SE, Serhan, CN, Yokomizo, T, Drazen, J, Rovati, GE, Hay, DW, Shimizu, T, Brink, C	Pharmacol Rev	2004
12615958	International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors Evans, JF, Dahlén, SE, Serhan, CN, Yokomizo, T, Nicosia, S, Drazen, J, Hay, DW, Shimizu, T, Brink, C	Pharmacol Rev	2003
7938166	International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes Smith, WL, Narumiya, S, Coleman, RA	Pharmacol Rev	1994