Reactome | ATP2A2 [endoplasmic reticulum membrane]

ATP2A2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-391962

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, AT2A2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P16615 ATP2A2

Gene Names

ATP2A2, ATP2B

Chain

chain:1-1042

Reference Genes

BioGPS Gene:488 ATP2A2

COSMIC (genes):ATP2A2 ATP2A2

CTD Gene:488 ATP2A2

dbSNP Gene:488 ATP2A2

ENSEMBL:ENSG00000174437 ATP2A2

ENSEMBL_homo_sapiens_GENE:ENSG00000174437.18 ATP2A2

HGNC:812 ATP2A2

KEGG Gene (Homo sapiens):488 ATP2A2

Monarch:488 ATP2A2

NCBI Gene:488 ATP2A2

OMIM:108740 ATP2A2

UCSC:P16615 ATP2A2

Reference Transcript

Other Identifiers

11718873_a_at

11718874_s_at

11740332_a_at

11754301_a_at

11754302_a_at

11758558_s_at

16756923

209186_PM_at

209186_at

212361_PM_s_at

212361_s_at

212362_PM_at

212362_at

239996_3p_x_at

239996_PM_x_at

239996_x_at

3431484

3431485

3431487

3431488

3431493

3431497

3431503

3431506

3431507

3431511

3431512

3431513

3431515

3431516

3431517

3431518

3431519

3431520

3431522

3431523

3431526

3431527

3431528

3431529

3431530

3431531

3431532

3431533

3431534

3431535

3431536

3431537

3431538

3431539

3431540

39790_at

39791_at

488

7958644

79971_r_at

83506_at

A_14_P112250

A_14_P119331

A_23_P53603

A_24_P141786

A_24_P73290

GE57875

GE86393

GE86414

GO:0000045

GO:0000166

GO:0002026

GO:0003012

GO:0003013

GO:0003723

GO:0003824

GO:0005215

GO:0005388

GO:0005509

GO:0005515

GO:0005524

GO:0005783

GO:0005789

GO:0005886

GO:0006811

GO:0006816

GO:0006874

GO:0006914

GO:0006984

GO:0006996

GO:0007155

GO:0008544

GO:0010460

GO:0010666

GO:0010882

GO:0012501

GO:0014801

GO:0014883

GO:0014898

GO:0016020

GO:0016192

GO:0016240

GO:0016529

GO:0016787

GO:0016887

GO:0019899

GO:0023052

GO:0030154

GO:0031095

GO:0032469

GO:0032470

GO:0033017

GO:0033292

GO:0034220

GO:0034599

GO:0034976

GO:0043226

GO:0044325

GO:0044548

GO:0045822

GO:0046872

GO:0048856

GO:0055065

GO:0055085

GO:0055119

GO:0061024

GO:0070050

GO:0070296

GO:0070588

GO:0086036

GO:0086039

GO:0090534

GO:0097470

GO:0098909

GO:0106222

GO:0140056

GO:0140657

GO:1900121

GO:1903233

GO:1903515

GO:1903779

GO:1990036

GO:1990456

HMNXSV003018967

HMNXSV003030484

Hs.1526.2.S1_3p_at

Hs.1526.2.S2_3p_a_at

Hs.205454.0.A1_3p_at

Hs.205454.0.A1_3p_x_at

ILMN_1655884

ILMN_1687375

ILMN_1815666

M23114_at

PH_hs_0024236

TC12000856.hg

g184100_3p_s_at

Participates

as a member of

ATP2A1-3 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ATP2A2 [platelet dense tubular network membrane]

Inferred To

ATP2A2 [endoplasmic reticulum membrane] (Bos taurus)

ATP2A2 [endoplasmic reticulum membrane] (Canis familiaris)

ATP2A2 [endoplasmic reticulum membrane] (Danio rerio)

ATP2A2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

ATP2A2 [endoplasmic reticulum membrane] (Gallus gallus)

ATP2A2 [endoplasmic reticulum membrane] (Mus musculus)

ATP2A2 [endoplasmic reticulum membrane] (Plasmodium falciparum)

ATP2A2 [endoplasmic reticulum membrane] (Rattus norvegicus)

ATP2A2 [endoplasmic reticulum membrane] (Sus scrofa)

sca-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001672.1, XP_005253945.1, NP_733765.1, XP_011536704.1

Guide to Pharmacology - Targets

841

OpenTargets

ENSG00000174437

HPA

ENSG00000174437-ATP2A2

GeneCards

P16615

Ensembl

ENSP00000440045, ENST00000539276, ENST00000308664, ENSG00000174437, ENSP00000311186

PRO

P16615

Pharos - Targets

P16615

Orphanet

15324

HMDB Protein

HMDBP01470

PDB

6LN6, 7W7V, 6JJU, 6LN9, 6LLE, 7E7S, 5ZTF, 6LN8, 7W7U, 6LN5, 6LLY, 7W7W, 6LN7, 7BT2, 7W7T

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	16
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.643	3
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P0DTC4 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [virion membrane] (R-COV-9698416)	0.527	2
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.524	3
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

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