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G-protein alpha (i):GDP [plasma membrane]
Stable Identifier
R-HSA-392164
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
ADP signalling through P2Y purinoceptor 12 (Homo sapiens)
Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Gi activation by P2Y purinoceptor 12 (Homo sapiens)
ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Adenylate cyclase inhibitory pathway (Homo sapiens)
Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Dissociation of the Gi alpha:G olf complex (Homo sapiens)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
Adenylate cyclase inhibitory pathway (Homo sapiens)
Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Dissociation of the Gi alpha:G olf complex (Homo sapiens)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)
ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)
ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Membrane estrogen receptors bind SRC (Homo sapiens)
G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
Participants
components
G alpha (i) [plasma membrane]
(Homo sapiens)
GDP [plasma membrane]
Participates
as an output of
G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
Dissociation of the Gi alpha:G olf complex (Homo sapiens)
as an input of
Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)
as a component of
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
This entity regulates
Positively
Membrane estrogen receptors bind SRC
(Homo sapiens)
Inferred To
G-protein alpha (i):GDP [plasma membrane]
(Bos taurus)
G-protein alpha (i):GDP [plasma membrane]
(Caenorhabditis elegans)
G-protein alpha (i):GDP [plasma membrane]
(Canis familiaris)
G-protein alpha (i):GDP [plasma membrane]
(Danio rerio)
G-protein alpha (i):GDP [plasma membrane]
(Dictyostelium discoideum)
G-protein alpha (i):GDP [plasma membrane]
(Drosophila melanogaster)
G-protein alpha (i):GDP [plasma membrane]
(Gallus gallus)
G-protein alpha (i):GDP [plasma membrane]
(Mus musculus)
G-protein alpha (i):GDP [plasma membrane]
(Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane]
(Saccharomyces cerevisiae)
G-protein alpha (i):GDP [plasma membrane]
(Schizosaccharomyces pombe)
G-protein alpha (i):GDP [plasma membrane]
(Sus scrofa)
G-protein alpha (i):GDP [plasma membrane]
(Xenopus tropicalis)
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