Gi activation by P2Y purinoceptor 12

Stable Identifier
R-HSA-392195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Gi activation by P2Y purinoceptor 12
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The G-protein alpha subunit exchanges GDP for GTP
Literature References
PubMed ID Title Journal Year
11196645 Identification of the platelet ADP receptor targeted by antithrombotic drugs

Vincent, D, Conley, PB, Yang, RB, Jantzen, HM, England, L, Li, G, Julius, D, Ramakrishnan, V, Nurden, A, Nurden, P, Hollopeter, G

Nature 2001
8554519 The human platelet ADP receptor activates Gi2 proteins

Schultz, G, Spicher, K, Nurnberg, B, Gachet, C, Laugwitz, KL, Ohlmann, P, Cazenave, JP

Biochem J 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of ADP:P2RY12:G-protein Gi (inactive) [plasma membrane]

Physical Entity
ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Gi activation by P2Y purinoceptor 12 (Bos taurus)
Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)
Gi activation by P2Y purinoceptor 12 (Canis familiaris)
Gi activation by P2Y purinoceptor 12 (Danio rerio)
Gi activation by P2Y purinoceptor 12 (Drosophila melanogaster)
Gi activation by P2Y purinoceptor 12 (Gallus gallus)
Gi activation by P2Y purinoceptor 12 (Mus musculus)
Gi activation by P2Y purinoceptor 12 (Rattus norvegicus)
Gi activation by P2Y purinoceptor 12 (Sus scrofa)
Gi activation by P2Y purinoceptor 12 (Xenopus tropicalis)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Harper, MT  (2009-11-02)
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Created
Jupe, S  (2009-02-27)
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