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PIK3CD [plasma membrane]
Stable Identifier
R-HSA-392274
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PI3-kinase p110 subunit delta, PK3CD_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD19 Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD19 Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Co-stimulation by ICOS (Homo sapiens)
PI3K binds ICOS (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
CD19 Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)
CD19 Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL is tyrosine phosphorylated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
K63polyUb-PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD19 Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD19 Signalosome [plasma membrane] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00329 PIK3CD
Gene Names
PIK3CD
Chain
chain:1-1044
Reference Genes
BioGPS Gene:5293 PIK3CD
COSMIC (genes):PIK3CD PIK3CD
CTD Gene:5293 PIK3CD
dbSNP Gene:5293 PIK3CD
ENSEMBL:ENSG00000171608 PIK3CD
HGNC:8977 PIK3CD
KEGG:hsa:5293 PIK3CD
Monarch:5293 PIK3CD
NCBI Gene:5293 PIK3CD
OMIM:602839 PIK3CD
UCSC:O00329 PIK3CD
Reference Transcript
RefSeq:XM_047422550.1 PIK3CD
RefSeq:XM_047422556.1 PIK3CD
RefSeq:XM_047422552.1 PIK3CD
RefSeq:XM_047422554.1 PIK3CD
RefSeq:XM_047422559.1 PIK3CD
RefSeq:XM_006710689.3 PIK3CD
RefSeq:XM_047422555.1 PIK3CD
RefSeq:XM_047422560.1 PIK3CD
RefSeq:XM_047422558.1 PIK3CD
RefSeq:XM_047422553.1 PIK3CD
RefSeq:XM_047422557.1 PIK3CD
RefSeq:NM_005026.3 PIK3CD
RefSeq:XM_047422551.1 PIK3CD
RefSeq:XM_006710687.3 PIK3CD
Participates
as a component of
K63polyUb-PI3K delta [cytosol] (Homo sapiens)
PI3K delta [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PIK3CD [cytosol]
Inferred To
Pi3K92E [plasma membrane]
(Drosophila melanogaster)
Pik3cd [plasma membrane]
(Mus musculus)
Pik3cd [plasma membrane]
(Rattus norvegicus)
PIK3CD [plasma membrane]
(Bos taurus)
PIK3CD [plasma membrane]
(Canis familiaris)
PIK3CD [plasma membrane]
(Gallus gallus)
PIK3CD [plasma membrane]
(Sus scrofa)
pik3cd [plasma membrane]
(Danio rerio)
Cross References
RefSeq
XP_047278509.1
,
XP_047278513.1
,
XP_047278511.1
,
XP_047278515.1
,
XP_047278507.1
,
XP_047278514.1
,
XP_047278516.1
,
XP_047278512.1
,
XP_047278510.1
,
XP_006710750.1
,
XP_047278506.1
,
XP_047278508.1
,
XP_006710752.1
,
NP_005017.3
ZINC - World Drugs
PK3CD_HUMAN
Guide to Pharmacology - Targets
2155
OpenTargets
ENSG00000171608
ENSEMBL
ENSP00000366563
,
ENSP00000513886
,
ENST00000481137
,
ENSP00000513889
,
ENST00000698713
,
ENST00000698712
,
ENSG00000171608
,
ENSP00000513890
,
ENST00000377346
ZINC - FDA approved
PK3CD_HUMAN
ZINC - Substances
PK3CD_HUMAN
ZINC target
O00329
PRO
O00329
GlyGen
O00329
PDB
5VLR
,
6OCO
,
9GCF
,
6OCU
,
5UBT
,
8S3R
,
5T8F
,
5M6U
,
7JIS
,
5DXU
,
7LM2
,
9GDI
,
6G6W
,
7LQ1
,
6PYR
,
6PYU
,
8BCY
ZINC - Investigational
PK3CD_HUMAN
IntEnz
2.7.1.137
HPA
ENSG00000171608-PIK3CD
GeneCards
PIK3CD
Pharos - Targets
O00329
Orphanet
PIK3CD
ZINC - Predictions - Purchasable
PK3CD_HUMAN
HMDB Protein
HMDBP01143
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.888
9
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