Reactome | PIK3CG [cytosol]

PIK3CG [cytosol]

Stable Identifier

R-HSA-392286

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PI3-kinase p110 subunit gamma, PK3CG_HUMAN

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PIK3CG [cytosol] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PIK3CG [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PIK3CG [cytosol] (Homo sapiens)
        
        ICOS:PI3K [plasma membrane] (Homo sapiens)
        
        Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        PI3K gamma [cytosol] (Homo sapiens)
        
        PIK3CG [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48736 PIK3CG

Gene Names

PIK3CG

Chain

chain:1-1102

Reference Genes

BioGPS Gene:5294 PIK3CG

COSMIC (genes):PIK3CG PIK3CG

CTD Gene:5294 PIK3CG

dbSNP Gene:5294 PIK3CG

ENSEMBL:ENSG00000105851 PIK3CG

HGNC:8978 PIK3CG

KEGG:hsa:5294 PIK3CG

Monarch:5294 PIK3CG

NCBI Gene:5294 PIK3CG

OMIM:601232 PIK3CG

UCSC:P48736 PIK3CG

Reference Transcript

Other Identifiers

11740212_x_at

11748086_a_at

17050134

206369_PM_s_at

206369_s_at

206370_PM_at

206370_at

239294_PM_at

239294_at

3018315

3018316

3018317

3018318

3018319

3018320

3018321

3018322

3018323

3018325

3018328

3018329

3018330

3018331

3018332

3018333

3018334

3018340

3018341

3018342

3018344

3018346

3018348

3018350

3018352

3018354

3018356

36287_at

5294

73732_at

8135363

A_14_P116511

A_14_P129537

A_14_P139317

A_23_P251359

A_24_P637651

A_33_P3304170

GE528823

GE618344

GE62760

GO:0001525

GO:0001819

GO:0001932

GO:0002250

GO:0002376

GO:0002407

GO:0002675

GO:0002679

GO:0003376

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0005944

GO:0006629

GO:0006897

GO:0006935

GO:0006954

GO:0006955

GO:0007155

GO:0007186

GO:0007200

GO:0007204

GO:0010595

GO:0010818

GO:0010897

GO:0012501

GO:0016020

GO:0016192

GO:0016301

GO:0016303

GO:0016310

GO:0016740

GO:0030593

GO:0032252

GO:0033628

GO:0035005

GO:0035022

GO:0035747

GO:0036092

GO:0042098

GO:0042110

GO:0042802

GO:0043303

GO:0043406

GO:0043491

GO:0045087

GO:0045765

GO:0046854

GO:0046875

GO:0046934

GO:0048015

GO:0048870

GO:0051897

GO:0055118

GO:0070527

GO:0071320

GO:0072672

GO:0097284

GO:0098542

GO:0106310

GO:0140096

GO:1903169

GO:2000270

HMNXSV003014794

HMNXSV003049302

Hs.122915.0.A1_3p_at

ILMN_1770433

ILMN_1894072

PH_hs_0002769

TC07000687.hg

g12620870_3p_a_at

g4505802_3p_at

g4505802_3p_x_at

Participates

as a component of

Inferred To

pikB [cytosol] (Dictyostelium discoideum)

pikG [cytosol] (Dictyostelium discoideum)

Ghost homologue of PIK3CG [cytosol] (Xenopus tropicalis)

Homologues of PIK3CG [cytosol] (Dictyostelium discoideum)

pikF [cytosol] (Dictyostelium discoideum)

pikC [cytosol] (Dictyostelium discoideum)

Pik3cg [cytosol] (Mus musculus)

Pik3cg [cytosol] (Rattus norvegicus)

pikA [cytosol] (Dictyostelium discoideum)

pikH [cytosol] (Dictyostelium discoideum)

Pi3K92E [cytosol] (Drosophila melanogaster)

PIK3CG [cytosol] (Bos taurus)

PIK3CG [cytosol] (Canis familiaris)

PIK3CG [cytosol] (Gallus gallus)

PIK3CG [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001269356.1, XP_005250500.1, NP_002640.2, NP_001269355.1

ZINC - World Drugs

PK3CG_HUMAN

Guide to Pharmacology - Targets

2156

OpenTargets

ENSG00000105851

ENSEMBL

ENST00000496166, ENST00000359195, ENSP00000419260, ENSP00000392258, ENSP00000352121, ENST00000440650

ZINC - FDA approved

PK3CG_HUMAN

ZINC - Substances

PK3CG_HUMAN

ZINC - Biogenic

PK3CG_HUMAN

ZINC target

P48736

PRO

P48736

PDB

3QK0, 4PS3, 4F1S, 3L13, 3ENE, 4AOF, 1HE8, 4XX5, 3R7R, 4EZL, 6FH5, 4FLH, 4XZ4, 3APF, 4URK, 4FJY, 4GB9, 6XRN, 4ANU, 3NZU, 3ML9, 4FHK, 7Z61, 2CHX, 2A5U, 6C1S, 4DK5, 3QJZ, 3R7Q, 3L17, 4EZJ, 8SC8, 3ZW3, 4PS8, 3QAR, 3P2B, 4WWP, 7JWE, 3APD, 5EDS, 8DP0, 7JX0, 6XRL, 3NZS, 3ML8, 4ANV, 2V4L, 5JHA, 2CHZ, 3CSF, 6T3B, 1E8Y, 5T23, 3L54, 7KKE, 3TL5, 7MEZ, 3L16, 3PS6, 3OAW, 4FA6, 4EZK, 4WWO, 3APC, 4KZC, 3ZVV, 5OQ4, 2A4Z, 4KZ0, 4G11, 4FJZ, 6XRM, 7JWZ, 5JHB, 2CHW, 4ANX, 1E8Z, 6T3C, 5G55, 3L08, 3MJW, 4FUL, 3T8M, 5KAE, 3DPD, 3DBS, 4PS7, 4WWN, 3QAQ, 4FAD, 3IBE, 5G2N, 3PRZ, 3TJP, 4J6I, 3SD5, 6AUD, 6GQ7, 3LJ3, 4FHJ, 4HLE, 3PRE, 4ANW, 3CST, 4HVB, 3S2A

ZINC - Investigational

PK3CG_HUMAN

ZINC - Metabolites

PK3CG_HUMAN

IntEnz

2.7.11.1, 2.7.1.153

HPA

ENSG00000105851-PIK3CG

Pharos - Targets

P48736

ZINC - Predictions - Purchasable

PK3CG_HUMAN

HMDB Protein

HMDBP01392

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q13370 PDE3B	2	p-S295-PDE3B [cytosol] (R-HSA-162419) PDE3B [cytosol] (R-HSA-162348)	0.499	3

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