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PIP5K1C [cytosol]
Stable Identifier
R-HSA-392427
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PIP5K1gamma
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)
FARP2:PIP5KIgamma [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
PIP5K1gamma:Talin-1 [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60331 PIP5K1C
Gene Names
PIP5K1C, KIAA0589
Chain
chain:1-668
Reference Genes
BioGPS Gene:23396 PIP5K1C
COSMIC (genes):PIP5K1C PIP5K1C
CTD Gene:23396 PIP5K1C
dbSNP Gene:23396 PIP5K1C
ENSEMBL:ENSG00000186111 PIP5K1C
ENSEMBL_homo_sapiens_GENE:ENSG00000186111.11 PIP5K1C
HGNC:8996 PIP5K1C
KEGG Gene (Homo sapiens):23396 PIP5K1C
Monarch:23396 PIP5K1C
NCBI Gene:23396 PIP5K1C
OMIM:606102 PIP5K1C
UCSC:O60331 PIP5K1C
Reference Transcript
RefSeq:NM_001195733.1 PIP5K1C
RefSeq:NM_012398.2 PIP5K1C
RefSeq:NM_001300849.1 PIP5K1C
Other Identifiers
11719031_at
11747904_a_at
16867115
212518_PM_at
212518_at
23396
32133_at
3846317
3846318
3846319
3846320
3846321
3846323
3846324
3846325
3846327
3846329
3846330
3846331
3846332
3846333
3846334
3846336
3846337
3846338
3846339
3846340
3846341
3846343
3846344
3846355
3846356
8032650
A_23_P330262
A_23_P78952
GO:0000166
GO:0001891
GO:0001931
GO:0002376
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005912
GO:0005925
GO:0006629
GO:0006661
GO:0006887
GO:0006897
GO:0006909
GO:0006935
GO:0007010
GO:0007155
GO:0010008
GO:0012505
GO:0016020
GO:0016079
GO:0016192
GO:0016301
GO:0016307
GO:0016308
GO:0016310
GO:0016740
GO:0023052
GO:0030036
GO:0030593
GO:0031410
GO:0032587
GO:0034330
GO:0034333
GO:0042995
GO:0043226
GO:0046488
GO:0046854
GO:0048488
GO:0048870
GO:0051896
GO:0052742
GO:0061024
GO:0070161
GO:0072583
GO:0098609
GO:0098793
HMNXSV003006674
HMNXSV003044885
Hs.275182.0.S1_3p_at
ILMN_1668514
PH_hs_0023440
TC19001048.hg
Participates
as a component of
FARP2:PIP5KIgamma [cytosol] (Homo sapiens)
PIP5K1gamma:Talin-1 [cytosol] (Homo sapiens)
as a member of
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
Inferred To
PIPkinA [cytosol]
(Dictyostelium discoideum)
Homologues of PIP5K1C [cytosol]
(Dictyostelium discoideum)
pip5k1c [cytosol]
(Xenopus tropicalis)
MSS4 [cytosol]
(Saccharomyces cerevisiae)
PIP5K59B [cytosol]
(Drosophila melanogaster)
its3 [cytosol]
(Schizosaccharomyces pombe)
PIP5K1C [cytosol]
(Bos taurus)
PIP5K1C [cytosol]
(Canis familiaris)
PIP5K1C [cytosol]
(Dictyostelium discoideum)
PIP5K1C [cytosol]
(Gallus gallus)
PIP5K1C [cytosol]
(Plasmodium falciparum)
PIP5K1C [cytosol]
(Sus scrofa)
Pip5k1c [cytosol]
(Mus musculus)
Pip5k1c [cytosol]
(Rattus norvegicus)
ppk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001287778.1
,
NP_036530.1
,
NP_001182662.1
ZINC - World Drugs
PI51C_HUMAN
Guide to Pharmacology - Targets
2165
OpenTargets
ENSG00000186111
ZINC - FDA approved
PI51C_HUMAN
ZINC - Substances
PI51C_HUMAN
ZINC target
O60331
ZINC - Biogenic
PI51C_HUMAN
PRO
O60331
PDB
3H1Z
,
3H85
,
2G35
ZINC - Investigational
PI51C_HUMAN
IntEnz
2.7.1.68
HPA
ENSG00000186111-PIP5K1C
GeneCards
O60331
Ensembl
ENSP00000466363
,
ENST00000335312
,
ENSP00000445992
,
ENSP00000335333
,
ENST00000537021
,
ENST00000589578
,
ENSG00000186111
,
ENSP00000444779
,
ENST00000539785
Pharos - Targets
O60331
ZINC - Predictions - Purchasable
PI51C_HUMAN
Orphanet
17478
HMDB Protein
HMDBP03290
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y490 TLN1
2
TLN1 [extracellular region]
(R-HSA-350693)
TLN1 [cytosol]
(R-HSA-350713)
0.611
8
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