Rap1 signal termination by Rap1GAPs

Stable Identifier
R-HSA-392513
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Rap1 signalling is terminated by the hydrolysis of bound GTP to GDP. The intrinsic GTPase activity of Rap1 is greatly enhanced by GTP-ase activating proteins (GAPs).
Literature References
PubMed ID Title Journal Year
1846040 Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells

McCormick, F, Polakis, PG, Evans, T, Rubinfeld, B

Proc Natl Acad Sci U S A 1991
9346962 Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product

Tsukamoto, N, Kurachi, H, Kubota, H, Wada, Y, Hattori, M, Minato, N, Iwai, K, Maeda, M

J Biol Chem 1997
15632203 Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets

Schultess, J, Danielewski, O, Smolenski, AP

Blood 2005
Participants
Participates
Catalyst Activity

GTPase activator activity of Rap1 GTPase-activating proteins [cytosol]

This event is regulated
Orthologous Events
Authored
Reviewed
Created
Cite Us!